Publication: Microglia and prion disease, a review
Authors
Brown, D.R. ; Kretzschrnar, H.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
t'rioii <lisciiscs are cIi;iractcrizc<l hy tlie
i ~ c c t i r ~ i i i l i ~otfi l~'~r~l i~ ~~I~IiI,i l tcrid iscifirrni (11' ii iitrriiiiil
cclluliir ~irrrtciii, I'rP? 'L'llic prioii Iiypotlicsis Iiiiltls tli;it
tlic ~iromss~ lcoiiloriniitioiiiicl haiigc fii>iiiI >rPCto ~ r l > ~ "
iiiidcr tlic i n l l i i c i i c c o f l ' r ~ > ~c«"i islitiites thc hasic
iiifcclioiis iiiccli;iiiisni iii prioii tliscascs. I t is s t i l l
iiiikiiown \vlictlicr p a l l i o l ~ i g i c a l cliiiiigcs iii tlicsc
(lisc;iscs, wliiclr iiicliitlc spongii'oini dcgeiicialioii, iicrvc
ccll !oss iirid gliosis, iirc tlic rcstilt 01' ~ieuroioxicity 01
k'rPS", loss of f i i i i c t i o i i iif I'rPC or soiiie otlier
mccli;rriisin. I<ccciit i~i i~itt.o Ciodirigs iisiiig ii syiitlictic
pcptidc of hiim;iii PrI'5itiplicatc iiiicir>gli;i iis ;i iiiitliiiior
of palliologicel chiiiiges. Tlie iiiccliaiiisiii IIt~hc toxicity
oí' tliis pcpti(lc iiivolvcs ncliviitioii oC microgli;~, oxi<l;itivc
slrcss, niitl dirccl iiitcriiclioirs willr I'rl'c-syi~tl~esiziirg
iiciiroiics tliiit rcdticc thcir :ihility to cope witli oxidstivc
stress. Microglis tliiis sccrii 11) ciiicrgc iis ii iiic<li;itor of
iicriroii;il dcgciicrnlioii i i i i c l ccll tlciillr iii pi-ioii iliscirscs.
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