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Molecular pathology of adenoid cystic carcinoma

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dc.contributor
dc.contributor.authorWei Shuanzeng
dc.contributor.authorPei Jianming
dc.contributor.authorZhang Paul J.L.
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-10-20T10:37:33Z
dc.date.available2025-10-20T10:37:33Z
dc.date.issued2025
dc.description.abstractAdenoid cystic carcinoma (ACC) is a slow-growing but locally aggressive salivary gland tumor. ACC is composed of ductal/tubular epithelial cells and basal/myoepithelial cells, which form cribriform, tubular, and solid growth patterns in variable combinations and dominance. ACC from different anatomic sites have similar morphological, molecular, and genetic changes. The key molecular alteration in ACC is chromosomal fusion/rearrangement/trans-location involving MYB or MYBL1, usually with NFIB as a fusion partner. In this review, we summarize the pathology and molecular alterations in ACC and their clinical significance
dc.formatapplication/pdf
dc.format.extent10
dc.identifier.citationHistology and Histopathology, volúmen 40, nº 10 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-915
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/167609
dc.languageeng
dc.publisherUniversidad de Murcia, Departamento de Histología e Histopatología
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAdenoid cystic carcinoma
dc.subjectPathology
dc.subjectPathogenesis
dc.subjectMolecular
dc.subjectGenetic
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleMolecular pathology of adenoid cystic carcinoma
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology Vol.40,nº10 (2025)