Publication: Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies
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Date
2007
Authors
Richardson, S. ; Mobasheri, A. ; Freemont, A.J. ; Hoyland, J.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Degeneration of the intervertebral disc (IVD)
is a major cause of low back pain affecting a large
percentage of the population at some point in their lives.
Consequently IVD degeneration and its associated low
back pain has a huge socio-economic impact and places
a burden on health services world-wide. Current
treatments remove the symptoms without treating the
underlying problem and can result in reoccurrence in the
same or adjacent discs. Tissue engineering offers hope
that new therapies can be developed which can
regenerate the IVD. Combined with this, development of
novel biomaterials and an increased understanding of
mesenchymal stem cell and IVD cell biology mean that
tissue engineering of the IVD may soon become a
reality. However for any regenerative medicine approach
to be successful there must first be an understanding of
the biology of the tissue and the pathophysiology of the
disease process. This review covers these key areas and
gives an overview of the recent developments in the
fields of biomaterials, cell biology and tissue
engineering of the IVD.
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