Publication: Histopathological findings in the
peritumoral edema area of human glioma
Authors
Wang, Xingfu ; Liu, Xueyong ; Chen, Yupeng ; Lin, Guoshi ; Mei, Wenzhong ; Chen, Jianwu ; Liu, Ying ; Lin, Zhixiong ; Zhang, Sheng
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-11-607
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info:eu-repo/semantics/article
Description
Abstract
Peritumoral brain edema (PTBE) is
considered to be one of the main biological behaviors of
brain glioma. However, the histopathological features of
PTBE remain imprecisely defined. We analyzed the
histopathological characteristics in the PTBE area of 22
cases of glioma. Microscopically, the pre-existing basic
structure in the edema area was still preserved but there
were varying degrees of loose tissue. The main
components of the edema tissue were scattered invasive
tumor cells, reactive cells, and various blood vessel
patterns. Invasive tumor cell density was significantly
higher in high-grade glioma than in low-grade glioma,
and the density was significantly higher in the area near
compared to the area far from the glioma. The Ki-67
proliferative index of the invasive tumor cells was higher
in high-grade glioma than in low-grade glioma, but the
index was not different in the area near compared to the
area far from the glioma. The microvessel pattern in
PTBE was primarily branching capillary. The
microvessel densities (MVDs) of CD34+ and CD105+
were higher in high-grade glioma and the area near the
glioma than in low-grade glioma and the area far from
the glioma. Compared to CD34+, the MVD of CD105+
exhibited a more significant downward trend in terms of
distance from the glioma. The most obvious types of reactive cells were reactive astrocytes and activated
microglia. The reactive astrocytes were positive for
nestin. The activated microglia emerged in the area near
the glioma in most cases and in the area far from the
glioma in more than half of the cases. In addition,
several cases displayed focal collections of small
lymphocytes around small blood vessels and tumor cells
arranged around a neuronal cell, and a limited number of
cases displayed giant dysmorphic neurons in an
edematous cortex. Our data indicate that PTBE is a
consequence of tissue reconstruction resulting from
tumor cell invasion and is an appropriate niche for the
growth and spread of glioma cells.
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Citation
Histology and histopathology, Vol. 30, nº 9 (2015)
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