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Fucosyltransferase 8 expression in breast cancer patients: A high throughput tissue microarray analysis

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dc.contributor.authorYue, Liling
dc.contributor.authorHan, Cuicui
dc.contributor.authorLi, Zubin
dc.contributor.authorLi, Xin
dc.contributor.authorLiu, Deshui
dc.contributor.authorLiu, Shulin
dc.contributor.authorYu, Haitao
dc.date.accessioned2021-07-05T07:56:57Z
dc.date.available2021-07-05T07:56:57Z
dc.date.issued2016
dc.description.abstractThe aim of this study was to compare the expression of fucosyltransferase 8 (FUT8) in breast cancer tissue and to investigate the relationship between this marker with tumor progression and its applicability to differential diagnosis. An immunohistochemical study was performed for FUT8 using the tissue microarray technique. In addition, the mRNA and protein levels of FUT8 in the tissue were also tested by real-time PCR and Western blot. There was a significant difference in cytoplasmic expression of FUT8 between breast cancer tissue and matched normal tissue (p<0.001). The percent of FUT8 staining in breast cancer tissues ranging from negative, weak positive, positive and strong positive were 2.7%, 40.2%, 54% and 3.2%, respectively. High FUT8 protein expression correlated with lymphatic metastasis (p=0.008) and with stage status (p=0.039). We detected that reduced FUT8 expression correlated with disease-free survival (p=0.02) and overall survival (p=0.04) of breast cancer patients. Expression of FUT8 can stratify breast cancer tissue and may be considered a prognostic marker for breast cancer patients.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.citationHistology and histopathology: Vol.31, nÂş5 (2016)
dc.identifier.doiDOI: 10.14670/HH-11-693
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/110381
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFUT8es
dc.subjectPrognosises
dc.subjectBreast canceres
dc.subjectTissue microarrayes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleFucosyltransferase 8 expression in breast cancer patients: A high throughput tissue microarray analysises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nÂş5 (2016)