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Sheng-Jiang-Yi-You decoction inhibits the inflammatory response by down-regulating the p38MAPK signaling pathway to alleviate Helicobacter pylori-associated gastritis

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dc.contributor
dc.contributor.authorLi Ze
dc.contributor.authorChen Ruirui
dc.contributor.authorTang Weihong
dc.contributor.authorZheng Xiaoya
dc.contributor.authorJin Xuefeng
dc.contributor.authorWang Zhongmin
dc.contributor.authorWu Qiao
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-10-28T13:15:07Z
dc.date.available2025-10-28T13:15:07Z
dc.date.issued2025
dc.description.abstractBackground. Helicobacter pylori (HP)-associated gastritis is an important factor in development of stomach cancer. Components of Sheng-Jiang-Yi-You decoction (SJYYD) exert gastroprotective effects. However, the effects and mechanism of SJYYD in HP-associated gastritis remain uncertain. Methods. HP bacterial solution (1×109 CFU/mL) was gavaged every other day for 14 days to construct an HP-associated gastritis mouse model. Male BALB/c mice were randomized into Sham, HP, HP+Standardized triple therapy (HP+Triplet), HP+SJYYD (0.4 mL/20 g), HP+Triplet+SJYYD, HP+anisomycin (ANI) (2.5 mg/kg/d, p38MAPK agonist, HP+ANI), and HP+ SJYYD+ANI groups (n=6). Gastric mucosal injury detection and rapid urease test for HP infection were conducted. HE staining for pathological damage and ELISA for pro-inflammatory factors and immuno-globulin G (IgG) content were performed. Measurement of p38 mitogen-activated protein kinase (p38MAPK) pathway-related factor expression was performed by qRT-PCR and western blot. Results. The increased IgG content and HP colonization rate indicated successful modeling. SJYYD caused attenuated gastric mucosal damage, with decreased ulcer index (UI), HP colonization rate, inflammatory cell infiltration, tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β levels in HP-associated gastritis mice. Moreover, SJYYD reduced p38MAPK, c-Jun N-terminal kinase (JNK), and extracellular regulated protein kinase (ERK) mRNA expression, as well as p-p38MAPK/p38MAPK, p-JNK/JNK, and p-ERK/ERK protein expression in gastric mucosa tissues of HP-associated gastritis mice. The above effects were reversed by further ANI treatment. Conclusion. SJYYD may attenuate HP-associated gastritis by inhibiting inflammatory response by down-regulating p38MAPK pathway, providing scientific evidence for clinical application of SJYYD in HP-associated gastritis treatment and promoting the development of therapeutic approaches in HP-associated gastritis
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dc.format.extent11
dc.identifier.citationHistology and Histopathology, Volúmen 40, nº11(2025), 1847-1857
dc.identifier.doihttps://doi.org/10.14670/HH-18-906
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/169790
dc.languageeng
dc.publisherUniversidad de Murcia, Departamento de Histología e Histopatología
dc.relationThis work was supported by Hangzhou Agricultural and Social Development Scientific Research Guidance Project [grant number 20220919Y052]; Key Project of Hangzhou Medical and Health Science and Technology Plan [grant number ZD20210044]; Zhejiang Provincial Traditional Chinese Medicine Science and Technology Program [grant number 2022ZA142]; Hangzhou Biomedicine and Health Industry Development Support Science and Technology Special Project [grant number 2023WJC009 and 2022WJC072
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHelicobacter pylori
dc.subjectGastritis
dc.subjectSheng-Jiang-Yi-You
dc.subjectInflammatory response
dc.subjectp38MAPK
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleSheng-Jiang-Yi-You decoction inhibits the inflammatory response by down-regulating the p38MAPK signaling pathway to alleviate Helicobacter pylori-associated gastritis
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.40, Nº11, (2025)