Experimental models for ageing research

Toniolo, Luana; Sirago, Giuseppe; Giacomello, Emiliana

Publication:
Experimental models for ageing research

dc.contributor.author	Toniolo, Luana
dc.contributor.author	Sirago, Giuseppe
dc.contributor.author	Giacomello, Emiliana
dc.date.accessioned	2023-05-24T10:08:08Z
dc.date.available	2023-05-24T10:08:08Z
dc.date.issued	2023
dc.description.abstract	Ageing is a biological process caused by the malfunctioning of multiple cellular mechanisms, ascribable to nine hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. These ageing pillars have three common traits: (i) they appear during normal ageing; (ii) their experimental intensification accelerates ageing; and (iii) their experimental reduction delays ageing. The evidence that the elderly are more prone to develop pathologies such as cancer, diabetes and degenerative diseases, together with data showing that the elderly population is steadily increasing, has stimulated an important effort to find specific countermeasures to physiological ageing. Unfortunately, the investigation of ageing processes and the search for countermeasures in humans is very difficult. Therefore, researchers must rely on a wide range of experimental models that span from unicellular to more complex organisms. Unfortunately, experimental models are not devoid of pitfalls, flaws or obstacles that can have an impact in ageing research. In the present review we describe the most exploited experimental models in the field, such as in vitro, animal and human models, highlighting the characteristics that justify their application in the laboratory routine, and translation to human research.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.citation	Histology and Histopathology Vol. 38, nº6 (2023)
dc.identifier.doi	https://doi.org/10.14670/HH-18-576
dc.identifier.issn	0213-3911
dc.identifier.issn	1699-5848
dc.identifier.uri	http://hdl.handle.net/10201/131403
dc.language	eng	es
dc.publisher	Universidad de Murcia, Departamento de Biologia Celular e Histiologia	es
dc.relation	Sin financiación externa a la Universidad	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Ageing	es
dc.subject	Age associated diseases	es
dc.subject	Life span	es
dc.subject	Health span	es
dc.subject	Experimental models	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología	es
dc.title	Experimental models for ageing research	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es