Publication: Epithelial-to-mesenchymal change of differentiation.
Authors
Guarino, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
ln embryonic morphogenesis, dramatic
changes from one state of differentiation to another take
place, and some epithelia transform into mesenchymal
cells endowed with the ability to migrate and to form
connective tissue. In vitro model systems have been
developed which have provided new insights into crucial
aspects of this differentiation change. Triggered perhaps
by either extracellular matrix or growth factors. this
phenotypic conversion involves a reorganization of the
cytoskeleton, and changes in both cell-cell and cellmatrix
interactions.
As embryonic and adult tissues contain the same,
albeit differently expressed, genetic information, one
could expect, under particular circumstances, conversion
to mesenchyme from epithelium to occur in adult tissues
too. Indeed, there is evidence that this change really
occurs in human diseases: some tissue reactions to
injury: the process of tumour invasion and metastasis;
and the development of carcinosarcomas, are al1
pathological conditions in which an epithelial conversion
into mesenchyme probably plays a role. Here, recent
observations on embryonic and in vitro epithelialmesenchymal
conversion are reviewed. and these data
are compared with findings from some pathological
situations. Many similarities emerge which further
strengthen the belief that this change in differentiation is
involved in the pathogenesis, and underlies the
pathological pattern of some diseases.
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