Publication:
Venous vasculature drives neovascularization and stroma formation in pancreatic neuroendocrine tumors via intussusceptive angiogenesis and vein intravasation

Simple item page
dc.contributor.authorDíaz-Flores Lucio
dc.contributor.authorGutiérrez Ricardo
dc.contributor.authorPino García Maria
dc.contributor.authorGonzález-Gómez Miriam
dc.contributor.authorCarrasco Jose Luis
dc.contributor.authorMadrid Juan Francisco
dc.contributor.authorDíaz-Flores Varela Lucio
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-10-28T07:42:16Z
dc.date.available2025-10-28T07:42:16Z
dc.date.issued2025
dc.description.abstractThe microenvironment of pancreatic neuroendocrine tumors (PanNETs) has been extensively studied; however, research on their venous vasculature has largely focused on tumor invasion and metastasis. This study aims to (a) evaluate the role of veins/venules in PanNET neovascularization, tumor intravasation, and stromal tract (trabecula) formation, including the potential involvement of intussusceptive angiogenesis (IA); and (b) compare the trabeculae observed in PanNETs with those found in hepatic cavernous hemangiomas (HCHs) where IA in veins plays an important role. To achieve these objectives, we conducted an integrated morphological approach encompassing primary PanNETs (n=42), hepatic metastases of PanNETs (n=4), and HCHs (n=11). Our findings in both primary and metastatic PanNETs reveal (a) the involvement of veins/venules in tumor neovascularization, with IA acting synergistically with sprouting angiogenesis, through the formation of pillars, meshes, and complex meshes (vessels that encapsulate tumor clusters-endothelium-coated tumor clusters); (b) the development of connective tissue around the neo-vasculature, potentially involving adventitial CD34-positive stromal cells/telocytes; and (c) a notable architectural resemblance between the trabeculae of PanNETs and those of HCHs. In conclusion, this work highlights the pivotal role of the preexisting venous vasculature in PanNET neovascularization, tumor intravasation, and stroma formation, with active participation of IA. These findings provide a pathophysiological foundation for future in-depth molecular investigations and may pave the way for new studies on therapeutic strategies targeting angiogenic mechanisms
dc.formatapplication/pdf
dc.format.extent22
dc.identifier.citationHistology and Histopathology, Volúmen 40, nº 11(2025), 1783-1804
dc.identifier.doihttps://doi.org/10.14670/HH-18-942
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/169649
dc.languageeng
dc.publisherUniversidad de Murcia, Departamento de Histología e Histopatología
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPanNETs
dc.subjectIntussusceptive angiogenesis
dc.subjectVessels that encapsulate tumor clusters (VETC) endothelium-coated tumor clusters
dc.subjectCD34+ stromal cells/telocytes
dc.subjectVeins
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleVenous vasculature drives neovascularization and stroma formation in pancreatic neuroendocrine tumors via intussusceptive angiogenesis and vein intravasation
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Diaz-Flores-40-1783-1804-2025.pdf
Size:
38.73 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology, Vol.40, Nº11, (2025)