Publication: Splicing and the single cell
Authors
Elliott, D.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The selection of alternative splice sites is an
important component of cell-specific gene regulation in
eukaryotic cells. Use of splice sites can be positively and
negatively regulated, and often physiologically
appropriate splice site choice is achieved by a balance of
the two. RNA elements controlling splice site choice are
found in both exons and introns, and these determine
management by the cellular splicing machinery.
However, the molecular basis of how the splicing
machinery responds to these signals in different cells is
somewhat of a paradox. Thus far the identified proteins
which bind to tissue/cell-specific regulatory elements in
mammals are expressed in many different tissues, and
not just in the regulating tissue. Potential tissue-specific
splicing regulators have been identified by nonbiochemical
means. However, alternative splicing
choices are likely to be affected by subtle differences in
the splicing machinery in different cells. In this review I
suggest that one important factor is the ratio of proteins
in different nuclear compartments, which might be
established in a cell type specific fashion.
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