Publication: Antigenic profile of human bronchial gland
Authors
Sánchez-Mora, N. ; Rendón-Henao, J. ; Monroy, V. ; Herranz Aladro, M. ; Álvarez-Fernández, Emilio
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Bronchial glands have been regarded as
modified salivary glands. It is well known that there no
previous reviews concerning the antigenic profile of the
bronchial wall. The aim of this study is a systematic
survey of the antigenic profile and to describe the
histology of normal human bronchial glands. Six
formalin-fixed, paraffin-embedded surgical specimens
were studied using a panel of 22 polyclonal and
monoclonal antibodies by the avidin-biotin-peroxidase
method. Bronchial glands disclosed a tubuloacinar
structure. The smallest ducts intercalated originated from
a cluster of secretory acini and converge to form an
excretory duct. No striated duct was observed. Acinar
united is composed by mucous, serous and mixed units.
Myoepithelial cells are found in relation to the
intercalated ducts and secretory acinis. Secretory cells of
bronchial glands reacted strongly with cytokeratin AE1
and moderately for CK7, CK18. Additionally, serous
acinar cells reacted with AE3, CK19, CK5/6/8/18,
CK8/18/19, and Leu7. Myoepithelial cells reacted
strongly with a-smooth muscle actin, CD10 and
CK34ßE12. Ductal system cells differed from acinar
secretory cells in expressing CK34ßE12 and HSP27. In
conclusion, the detailed knowledge of the
immunohistochemical reactivities of normal cell types of
normal human bronchial glands will prove useful in
studies of bronchial pathology, especially of neoplastic
processes.
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