Browsing by Subject "zinc"

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    Erosión y desertificación.-Environmental risks associated to wind erosion in a metal mining area from SE Spain
    Garcia Fernández, G.; Romero Díaz, A.; Universidad de Murcia
    ABSTRACT Soils and mining wastes from the Mediterranean mining area placed in the Sierra Minera Mountains are highly enriched in heavy metals such as lead and zinc, but also other metals such as cadmium and arsenic. Wind erosion in this area could be considered extremely high and hazards associated to this eroded sediments seems to be high because the huge amount of metals present in this wastes. Therefore, combination of high erosion rates and high metal concentration in this mining waste, make those environmental risks can be considered high for the surrounding ecosystems, but also for public health of the nearby villages and towns. In order, to study these wind erosion processes over these mining materials, some experiments for the evaluation of the transportation of soil particles were carried out. Erosion rates in this realm is particularly important during spring months, when increased activity of the eastern winds brings intense soil dragging, with strong effects on the metals dispersion, including the massive removal of sediments.
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    On the metal cofactor in the Tyrosinase family
    (MDPI, 2018-02-23) Solano, Francisco; Bioquímica y Biología Molecular B e Inmunología
    The production of pigment in mammalian melanocytes requires the contribution of at least three melanogenic enzymes, tyrosinase and two other accessory enzymes called the tyrosinase-related proteins (Trp1 and Trp2), which regulate the type and amount of melanin. The last two proteins are paralogues to tyrosinase, and they appeared late in evolution by triplication of the tyrosinase gene.Tyrosinase is a copper-enzyme, and Trp2 is a zinc-enzyme. Trp1 has been more elusive, and the direct identification of its metal cofactor has never been achieved. However, due to its enzymatic activity and similarities with tyrosinase, it has been assumed as a copper-enzyme. Recently, recombinant human tyrosinase and Trp1 have been expressed in enough amounts to achieve for the first time their crystallization. Unexpectedly, it has been found that Trp1 contains a couple of Zn(II) at the active site This review discusses data about the metal cofactor of tyrosinase and Trps. It points out differences in the studied models, and it proposes some possible points accounting for the apparent discrepancies currently appearing. Moreover, some proposals about the possible flexibility of the tyrosinase family to uptake copper or zinc are discussed.