Browsing by Subject "spirocycles"

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    Synthesis and Reactivity of Model Intermediates Proposed for the Pd-Catalyzed Remote C−H Functionalization of N‐(2- Haloaryl)acrylamides
    (2017-11-14) Pérez-Gómez, Marta; Navarro, Leticia; Saura-Llamas, Isabel; Bautista, Delia; Lautens, Mark; García-López, José-Antonio; Química Inorgánica
    We have studied the possible reaction pathways operating in the Pd-catalyzed remote C–H functionalization of N-(2-haloaryl)-acrylamides from an organometallic approach. We have isolated and characterized several reaction intermediates, such as σ-alkyl-Pd complexes and spiro C,C-palladacycles, and evaluated the role of the base and the auxiliary ligands coordinated to Pd in the remote C–H activation process. In addition, the reactivity of these intermediates toward different unsaturated species like benzyne, alkynes or isocyanides has been studied in order to gain further insight on the reaction mechanism leading to functionalized spiro-oxoindoles.