Browsing by Subject "Zearalenone"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Publication
    Restricted
    Proteome changes induced by a short, non-cytotoxic exposure to the mycoestrogen zearalenone in the pig intestine
    (Elsevier, 2020-07-30) Soler, Laura; Stella, Alexandre; Pallarés, Francisco José; Lahjouji, Tarek; Burlet Schiltz, Odile; Oswald, Isabelle P.; Seva Alcaraz, Juan; Anatomía y Anatomía Patológica Comparadas
    Intestinal epithelial homeostasis is regulated by a complex network of signaling pathways. Among them is estrogen signaling, important for the proliferation and differentiation of epithelial cells, immune signaling and metabolism. The mycotoxin zearalenone (ZEN) is an estrogen disruptor naturally found in food and feed. The exposure of the intestine to ZEN has toxic effects including alteration of the immune status and is possibly implicated in carcinogenesis, but the molecular mechanisms linked with these effects are not clear. Our objective was to explore the proteome changes induced by a short, non-cytotoxic exposure to ZEN in the intestine using pig jejunal explants. Our results indicated that ZEN promotes little proteome changes, but significantly related with an induction of ERα signaling and a consequent disruption of highly interrelated signaling cascades, such as NF-κB, ERK1/2, CDX2 and HIF1α. The toxicity of ZEN leads also to an altered immune status characterized by the activation of the chemokine CXCR4/SDF-1 axis and an accumulation of MHC-I proteins. Our results connect the estrogen disrupting activity of ZEN with its intestinal toxic effect, associating the exposure to ZEN with cell-signaling disorders similar to those involved in the onset and progression of diseases such as cancer and chronic inflammatory disorders.