Browsing by Subject "Vitamin E"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Restricted
    Serum vitamins A and E at mid-pregnancy and their relationships with both maternal and cord blood antioxidant status and perinatal conditions: The NELA Cohort
    (2023-06-02) Sánchez-Campillo, María; Gázquez García, Antonio; Serrano-Munuera, Ana; Bañón Arnao, Marino; Avilés Plaza, Francisco Valeriano; Garcia-Serna, Azahara M.; Noguera Velasco, José Antonio; Martínez López de Castro, Ana María; Martínez Gracia, Carmen; Suárez Martínez, Clara; Santaella-Pascual, Marina; Vioque, Jesús; Montoya-Hernández, Carmen; Ballesteros Meseguer, Carmen; Sánchez Ferrer, María Luisa; Pérez Fernández, Virginia; Morales Bartolomé, Eva; García-Marcos Álvarez, Luis Vicente; Larqué Daza, Elvira; Nela Study Group; Tecnología de Alimentos, Nutrición y Bromatología; Facultad de Veterinaria
    Introduction: Most of the pregnant women do not achieve the recommended dietary intake of vitamins A and E. These vitamins may counteract oxidative stress involved in some adverse perinatal outcomes. We aimed to assess the associations between maternal vitamin A and E at mid-pregnancy with both maternal and fetal outcomes and to identify possible early biomarkers during pregnancy to predict and prevent oxidative stress in the offspring. Methods: Data on dietary and serum levels of vitamins A and E were collected from 544 pregnant women from the Nutrition in Early Life and Asthma (NELA) study, a prospective mother-child cohort set up in Spain. Results: There were large discrepancies between low dietary vitamin E intake (78% of the mothers) and low serum vitamin E levels (3%) at 24 weeks of gestation. Maternal serum vitamins A and E at mid-pregnancy were associated with higher antioxidant status not only in the mother at this time point (lower hydroperoxides and higher total antioxidant activity [TAA]) but also with the newborn at birth (higher TAA). Gestational diabetes mellitus (GDM) was negatively associated with maternal serum vitamin A (OR: 0.95 CI: 0.91–0.99, p = 0.009) at mid-pregnancy. Nevertheless, we could not detect any association between GDM and oxidative stress parameters. Conclusions: In conclusion, maternal vitamin A and E serum levels may be used as an early potential biomarker of antioxidant status of the neonate at birth. Control of these vitamins during pregnancy could help avoid morbid conditions in the newborn caused by oxidative stress in GDM pregnancies.
  • Thumbnail Image
    Publication
    Open Access
    Vitamin E action on oxidative state, endothelial function and morphology in long-term myocardial preservation
    (Murcia : F. Hernández, 2010) Álvarez-Ayuso, Lourdes; García Gómez-Heras, Soledad; Jorge, Eduardo; Guardiola, José M.; Torralba, Amalia; Granado, Fernando; Millán, Isabel; Roda, Jorge R.; Calero, Patricia; Fernández-García, Héctor; García-Poblete, Eduardo
    . This study assesses the effects of a vitamin E analogue, Trolox, on the oxidative state, endothelial function and morphology in experimental heart transplantation. Heterotopic heart transplantation was carried out in pigs: untreated after 2 and 24 hours of ischemia and treated with Trolox after 24 hours of ischemia. Prolonged preservation of donor hearts was achieved with continuous perfusion and University of Wisconsin solution, in which acid-base balance and enzymes were determined during the procedure. In recipients, hemodynamic and biochemical parameters were determined at baseline and during reperfusion. Trolox diminished the pH of the preservation solution (p<0.01), the left ventricle of the transplanted heart recovered a systolic pressure equaling that of the 2h group and higher than that of the untreated 24h group (p<0.01), the antioxidant levels were not decreased and the glutathione reductase level was maintained throughout the first part of reperfusion. In this group also there was a direct correlation between the concentration of this enzyme and the antioxidant levels (p<0.001). Although the endothelin concentrations increased, the change was less marked in the Trolox group than in the untreated 24h group (p<0.01). Morphologically, mitochondria and myocardial vessels presented a normal structure in the Trolox group, and interstitial edema, inflammatory infiltrate and contraction bands were less prominent than in the untreated group. All these effects indicate that Trolox protected the transplanted heart, at least partially, against ischemia-reperfusion injury