Browsing by Subject "Vital pulp therapy"

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    Biocompatibility of a HA/β-TCP/C scaffold as a pulp-capping agent for vital pulp treatment: an in vivo study in rat molars
    (MDPI, 2021-04-08) Guerrero Gironés, Julia; Alcaina Lorente, Antonio; Ortiz Ruiz, Clara; Ortiz Ruiz, Eduardo; Pecci Lloret, María P.; Ortiz Ruiz, Antonio José; Rodríguez Lozano, Francisco Javier; Pecci Lloret, Miguel R.; Dermatología, Estomatología, Radiología y Medicina Física
    Bioceramic materials possess desirable biological properties, highlighting their non-reactivity and osteoconductivity. Their use has been extended in vital pulp treatment. The purpose of this study was to evaluate and compare the effects of beta-tricalcium phosphate (β-TCP), hydroxyapatite (HA), and collagen (C) scaffold with mineral trioxide aggregate (MTA) on the vital pulp of rat molars. Thirty-two molars of Sprague–Dawley rats underwent direct pulp capping with β-TCP/HA/C (n = 16) and MTA (n = 16). After 30 days, the following parameters were evaluated in the tested samples: the degree of pulp inflammation and pulp vitality, the presence of reparative dentin, the homogeneity of the odontoblastic layer, and the presence of pulp fibrosis. No statistically significant differences were observed between HA/β-TCP/C and MTA in terms of the degree of inflammation (p = 0.124). Significant differences were found in reparative dentin formation between the treatment groups (p = 0.0005). Dentin bridge formation was observed in the MTA-treated group. The local action of HA/β-TCP/C is similar to that of MTA when used as an agent for pulp vital treatment in terms of absence of inflammation and maintenance of pulp vitality, although there are significant differences between both materials regarding the formation of dentin bridges.
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    Open Access
    Effect of N-Hexyl Cyanoacrylate, Calcium Hydroxide Plus Iodoform and Two Calcium-Silicate-Based Restorative Cements on Pulp Repair
    (OMICS international, 2018-09-28) Pérez Silva, Amparo; Serna Muñoz, Clara; Casimiro de Andrade, JD.; Pinhao Ferreira, A.; Ortiz Ruiz, Antonio José; Dermatología, Estomatología, Radiología y Medicina Física
    Objective: The objective of this study was to evaluate the histological response of rat molars to four materials placed on the dental pulp. Methods: We used 24 female Wistar rats (6 per group). The pulp chamber roof of the first and second upper molars was perforated. After control of bleeding (<5 minutes), a pulp coating material (ProRoot®MTA, IfabondTM, Calcipast+I or BiodentineTM) was placed. After 30 days of treatment, the molars were observed under an optical microscope. Results: ProRoot®MTA produced no inflammation of any pulp (p<0.0005). With Calcipast+I, inflammation was absent only in 18.7% of the pulps. All samples in all groups presented pulpal vitality. The ProRoot®MTA, IfabondTM and BiodentineTM groups showed a dentin bridge and reparative dentin in all pulps. Only ProRoot®MTA showed a completely regular odontoblastic layer (p<0.0005). IfabondTM and BiodentineTM generated an irregular odontoblastic layer in all pulps (p<0.00l) and Calcipast+I showed 50% regular and 50% irregular layers. All samples treated with ProRoot®MTA (p<0.0005), 81.25% with Calcipast+I and only 37.5% of those treated with IfabondTM and BiodentineTM (p<0.0005) showed fibrosis. In all groups, calcifications appeared in areas outside the dentin bridge (p=0.027). Conclusion: Although ProRoot®MTA had the best performance, the response of the pulp of rat molars to the materials used was similar according to the histological criteria of degree of inflammation and pulpal vitality. The regularity or irregularity of the odontoblastic layer did not influence the presence of a dentin bridge.