Browsing by Subject "Transitional B cells"

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    Influence and role of regulatory B cells in organ transplantation: the state of the art, prospects, and emerging insights
    (MDPI, 2025-11-07) Fernández-González, Marina; Llorente, Santiago; Galián, José Antonio; Botella, Carmen; González-López, Rosana; Alegría, María José; Hita, Alicia; Moya-Quiles, María Rosa; Martinez-Banaclocha, Helios; Muro-Pérez, Manuel; Muro, Javier; Minguela, Alfredo; Legaz Pérez, Isabel; Muro, Manuel; Ciencias Sociosanitarias; Facultad de Química
    B cells have attracted increasing interest in the field of organ transplantation due to their newly discovered immunoregulatory properties in alloimmune responses. Traditionally, B cells have been primarily associated with adaptive immunity to foreign substances and alloreactive immune response to allografts, differentiating into antibody-producing plasma cells or memory cells upon antigen recognition and T cell collaboration. However, the existence of B cells with regulatory functions (Bregs) in humans has been widely confirmed, highlighting the presence of this subset, which has immunosuppressive properties and which might contribute to allograft tolerance, within the B cell compartment in humans and mice. In this mini review, we summarize all the information available in the published reports about the role of regulatory B cells in solid organ transplantation.