Browsing by Subject "Tomography"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Publication
    Open Access
    Evaluación de tomografía computarizada y score SOFA pulmonar: relación de evaluación en pacientes con covid-19 y mortalidad en UCI
    (Universidad de Murcia. Servicio de publicaciones, 2023) Martinelli, Anna Laura; Bonatto, Simonei; Silva, Carla Luiza; Reche, Pericles Martim; Sloboda, Dyenily Alessi; Cavalheiro, Ana Paula Garbuio
    Objetivo: Evaluar la gravedad pulmonar de pacientes con Covid-19 a través de la correlación del puntaje SOFA pulmonar con el de afectación pulmonar en Tomografía Computarizada de Tórax. Método: Se trata de un estudio epidemiológico retrospectivo analítico descriptivo realizado en una Unidad de Cuidados Intensivos que buscó analizar el compromiso pulmonar de pacientes con Covid a través del cálculo del SOFA pulmonar relacionando la Tomografía de Tórax y si estos tenían relación con el desenlace clínico. Resultados: La población de estudio incluyó a 704 pacientes, de los cuales el 43,7% eran mujeres y el 56,2% hombres, con una edad media de 61 años y una estancia media de 13 días. La mayoría de la población presentó afectación pulmonar del 75%, puntuación SOFA pulmonar de 2 y relación PaO²/FiO² entre 100 y 200. Conclusión: Los pacientes que tenían afectación pulmonar más extensa en consecuencia tenían menor relación PaO²/FiO² y permanecían hospitalizados por un tiempo más largo con una mayor incidencia de muerte.
  • Thumbnail Image
    Publication
    Open Access
    Fast normalized cross-correlation for template matching with rotations
    (2024-06-19) Almira Picazo, Jose María; Phelippeau, Harold; Martinez-Sanchez, Antonio; Ingeniería de la Información y las Comunicaciones
  • Thumbnail Image
    Publication
    Open Access
    Ultrastructure and 3D transmission electron tomography of collagen fibrils and proteoglycans of swollen human corneal stroma
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2019) Akhtar, S.; Petrovski, G.; Albert, R.; Alkanaan, A.; Kirat, O.; Khan, A.D.; Almubrad, T.
    Background. The transparency of the cornea is regulated by the unique organization of collagen fibrils (CFs) which is maintained by proteoglycans (PGs). The interlacing of CF lamellae in the anterior stroma provides the biomechanical properties of the cornea. Objective. To investigate the alterations of CFs and PGs in the swollen cornea, with special reference to the anterior stroma by using electron microscopy and 3D ultrastructural tomography. Method. Nine healthy normal scleral corneal rings (age from 40 to 65 years) were hydrated individually in deionised water to induce swelling in the cornea. Three of them were hydrated for 2hr whereas the other three were hydrated for 48hr. The remaining three scleral normal corneal rings were used as a control.The corneas were processed for electron microscopy (E M) to study the CFs and PGs. Ultrathin sections were observed using transmission electron microscopy (JOEL 1400) and digital images of CFs, PGs and lamellae were captured using a bottom mounted Quemesa camera and iTEM Soft Imaging System. The software program ‘Composerx64, version 3.4.2.0’ was used to construct individual 3D images from 120 digital images taken from -60 to +60 degree angles. Results. The 3D tomography showed the degeneration of microfibrils within the CFs of the swollen cornea. The CF diameter was significantly reduced and the interfibrillar spacing significantly increased in both the 2hr and 48hr hydrated corneas compared to the normal cornea. Within the hydrated corneas, the CF diameter was smaller and the interfibrillar spacing was increased in the middle and posterior stroma compared to the anterior stroma. The PG area in both the 2hr and the 48hr hydrated cornea was reduced in the anterior stroma, whereas it was increased in middle and posterior stroma compared to the normal cornea. The density of the PGs in both the 2hr and the 48hr samples, was reduced compared to the density of PGs in the normal cornea. Conclusion. The CFs, PGs and lamellae had degenerated, caused by swelling. 3D imaging demonstrated that the impairment of the microfibrils and PGs within the CF, is caused by the excessive hydration or swelling in the anterior as well as in the middle and posterior stroma. The lamellae of the anterior stroma which provides the biomechanical strength in the normal cornea, had degenerated in the swollen corneas due to the presence of the damaged CFs and PGs.