Browsing by Subject "Score"

Now showing 1 - 3 of 3
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    Application of a score for evaluation of pain, distress and discomfort in pigs with lameness and prolapses: correlation with saliva biomarkers and severity of the disease
    (2019-10) Contreras Aguilar, María Dolores; Escribano Tortosa, Damián; Martínez Miró, Silvia; López Arjona, Marina; Peres Rubio, Camila; Martínez Subiela, Silvia; Cerón Madrigal, José Joaquín; Tecles Vicente, Fernando; Medicina y Cirugía Animal
    A score system was used to evaluate pain, distress and discomfort in healthy pigs and pigs with two different diseases: lameness and rectal prolapse. In addition, correlations between the results of this score and a panel of salivary biomarkers and severity of disease were studied. This panel included biomarkers of stress (cortisol, salivary alpha-amylase (sAA), total esterase activity (TEA), butyrylcholinesterase (BChE) and lipase (Lip)), im- munity (adenosine deaminase isozymes 1 (ADA1) and 2 (ADA2)) and oxidative status (uric acid (UA), Trolox equivalent antioxidant capacity (TEAC), cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of saliva (FRAS), advanced oxidation protein products (AOPP) and hydrogen peroxide (H2O2)). Based on their score, diseased animals were subdivided in those without and with evident pain. Lame pigs and prolapsed pigs with pain showed higher salivary levels of cortisol, sAA, TEA, BChE, ADA1 and ADA2 compared with the healthy pigs. In addition, the prolapsed pigs with pain showed higher levels of FRAS, AOPP and H2O2 compared with the healthy animals. Salivary cortisol, TEA, BChE, ADA isozymes 1 and 2, FRAS and AOPP correlated with the pain score. This five-point pain score system can be easily applied to lame and prolapsed pigs, and salivary bio- markers could be used as an additional tool for pain assessment in those pigs.
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    La clave crítica bien temperada: Baquero Goyanes en su partitura.
    (Universidad de Murcia, Servicio de Publicaciones, 2023) Cervera Salinas, Vicente
    Este artículo traza un itinerario por la obra crítica de Mariano Baquero Goyanes desde su reconocida afición al arte de la música. Desde sus primeras investigaciones en los años cincuenta, como en “Tiempo en tempo en la novela” (1954), las referencias a las técnicas y formas musicales así como a la historia de la música fecundan e iluminan de modo original y precursora su aportación científica a la crítica literaria. Las páginas dedicadas a las estructuras musicales en la novelística contemporánea, ya en los años setenta, revelan su madurez crítica y la amplitud del campo de visión del fenómeno artístico.
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    Synovial histopathology in common orthopaedic joint conditions assessed with a modified Krenn synovitis score
    (2026) Lew Schon; Zijun Zhang; Biología Celular e Histología; Universidad de Murcia, Departamento de Biologia Celular e Histiologia
    Purpose. Synovial pathology impacts joint disease progression and clinical outcome. The goal of this study was to modify Krenn synovitis score for more accurate and comprehensive evaluation of common orthopaedic joint conditions. Methods. A total of 31 synovial samples were collected during foot and ankle surgery. Synovial sections were stained with hematoxylin and eosin, and picrosirius red. Immunohistochemistry for CD3 and α smooth muscle actin (α-SMA) was performed for inflammatory infiltration and fibroblast activation. Synovitis was evaluated with Krenn synovitis score and a modified Krenn synovitis score (MKSS), where the original subcategories of inflammatory infiltration and stromal cellularity were replaced with the density of CD3+T cells and collagen intensity, respectively. Results. Of 31 synovial samples, the average Krenn synovitis score was 1.5±1.3 and MKSS was 1.8±1.2 (p>0.05). The two scores were positively correlated in assessing synovial pathology (r=0.6; p<0.001). The dominant subcategory shifted from stromal cellularity (64%) in Krenn synovitis score to the density of CD3+T cells (80%) in MKSS. By MKSS classification, but not Krenn synovitis score, type III collagen intensity and the ratio of type III over type I collagen increased in the synovitis group. The density of α-SMA+cells did not correlate with the intensity of synovial collagen and was not different between synovitis and non-synovitis samples. Conclusion. While maintaining the concept and basic elements of the Krenn synovitis score, MKSS incorporated more accurate inflammatory infiltration and detailed fibrosis. It could provide a more comprehensive evaluation of synovial pathology in common orthopaedic joint conditions.