Browsing by Subject "SYNTHESIS"
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- PublicationOpen Access2-Arylacetamides as Versatile Precursors for 3-Aminoisocoumarin and Homophthalimide Derivatives: Palladium-Catalyzed Cascade Double Carbonylation Reactions(Wiley, 2016-07-11) Frutos-Pedreño, Roberto; García-López, José-Antonio; García-López, José-Antonio; Química Inorgánica
- PublicationOpen AccessExploring the Conversion of Macrocyclic 2,2 '-Biaryl Bis(thioureas) into Cyclic Monothioureas: An Experimental and Computational Investigation(American Chemical Society, 2018-10-23) Alajarín, Mateo; Lopez-Leonardo, Carmen; Orenes, Raul A.; Pastor Vivero, Aurelia; Sanchez-Andrada, Pilar; Vidal, Angel; Química OrgánicaMacrocyclic bis(thioureas) derived from 2,2’-biphenyl and binaphthyl skeletons have been synthesized by reaction of 2,2’-diaminobiaryl and 2,2’-bis(isothiocyanato)biaryl derivatives. The splitting of these bis(thioureas) into two units of the respective cyclic monothioureas has been monitored by NMR, shedding some light on the factors that control these processes. Additionally, a computational study revealed up to three mechanistic paths for the conversion of the 2,2’-biphenyl-derived bis(thiourea) into the corresponding monothiourea. The proposed mechanisms account for the participation of a molecule of water as an efficient proton-switch, as well as for different classes of putative intermediates. The computational study also supports the ability of the thiourea group to participate in a plethora of processes, such as prototropic equilibria, sigmatropic shifts, heteroene and retro-heteroene reactions, and cis-trans isomerizations.
- PublicationOpen AccessSynthesis of [3.4]-Spirooxindoles through Cascade Carbopalladation of Skipped Dienes(Wiley, 2020-03-24) Azizollahi, Hamid; Pérez-Gómez, Marta; Mehta, V. P.; García-López, José-Antonio; García-López, José-Antonio; Química Inorgánica
- PublicationOpen AccessTrapping σ-Alkyl–Palladium(II) Intermediates with Arynes Encompassing Intramolecular C-H Activation: Spirobiaryls through Pd-Catalyzed Cascade Reactions(Wiley, 2016-11-07) Pérez-Gómez, Marta; García-López, José-Antonio; García-López, José Antonio; Química Inorgánica
- PublicationOpen Accessσ-Alkyl-PdII Species for Remote C-H Functionalization(Wiley-VCH, 2017-04-07) García-López, José-Antonio; Mehta, V. P.; García-López, José-Antonio; Mehta, V. P.; Química Inorgánica