Browsing by Subject "Rab"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Open Access
    Rab family small GTPases-mediated regulation of intracellular logistics in neural development
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Shikanai, Mima; Yuzaki, Michisuke; Kawauchi, Takeshi
    Rab family small GTPases play essential roles in various cellular events via the regulation of intracellular logistics comprising a large number of membrane traffic pathways. Emerging evidence reveals the physiological roles of Rab proteins in several tissues, including developing brains. Many Rab proteins, such as Rab5, Rab6, Rab7, Rab8, Rab10, Rab11, Rab17 and Rab18, are shown to regulate neurite outgrowth in PC12 cells and/or axon and dendrite formation in primary cultured neurons. Recent studies have also revealed in vivo roles of several Rab family small GTPases in brain development and its related neurological disorders. In this review, we introduce the physiological function of Rab family proteins in neural development with particular focus on neurite outgrowth and neuronal migration.
  • Thumbnail Image
    Publication
    Open Access
    Regulation of EGFR endocytic trafficking by rab proteins
    (Murcia : F. Hernández, 2006) Ceresa, B.P.
    The Epidermal Growth Factor Receptor (EGFR) is a member of the receptor tyrosine kinase family and has important roles in development and cancer. Through ligand stimulation, the EGFR initiates a number of biochemical pathways that integrate to form specific physiological responses. In addition to these signaling pathways, the ligand stimulation also causes the EGFR to internalize and be transported through the endocytic pathway. The endocytic pathway regulates the rate of EGFR degradation and recycling, as well as the signaling mediated by the EGFR. In this review, the role of rabs, a family of small molecular weight guanine nucleotide binding proteins, is examined in how they regulate endocytic trafficking