Browsing by Subject "Pulmonary edema"

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    Electron microscopic pathological patterns of alveolar septum in acute dextran-induced and alloxan-induced pulmonary edema in dogs
    (Murcia : F. Hernández, 1988) Koji Nakahara; Michio Arakawa; Kenjiro Kambara; Hiroshi Oda; Senri Hirakawa; Shizuko Shoumura; Hideo Isono
    We studied the incidence of electron microscopic pathological patterns of the alveolar septum observed 30 min after induction of pulrnonary edema by dextran-70 infusion (6 dogs, dextran group) and by alloxan injection (6 dogs, alloxan group). For comparable amounts of extravascular lung water in both dextran and alloxan groups, which were twice as much as control group (6 dogs), we characterized the pathological changes. The incidence of the electron microscopic pathological patterns that appeared in dextran group compared with that in control group was significantly high in terms of the widening of the interstitial space. dispersion and disarray of collagen fibrils, and erythrocytes in the interstitial space. The incidence in alloxan group compared with that in control group was significantly high in terms of the swelling of epithelial cells and endothelial cells as well as the widening of the interstitial space, and dispersion and disarray of collagen fibrils. We conclude that dextran causes interstitial changes exclusively and alloxan causes cellular changes primarily coupled with secondary interstitial changes in acute pulmonary edema.
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    Ultrastructural substrates for increased lung water content in experimental pulmonary edema
    (Murcia : F. Hernández, 1993) Oda, H.; Arakawa, M.; Kambara, K.; Nakahara, K.; Segawa, T.; Ando, F.; Kawada, T.; Hirakawa, S.; Shoumura, S.; Isono, H.
    We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n=12) or alloxan (n=6) administration. Six other dogs served as controls. Extravascular lung water content was measured by the thermal-dye double indicator dilution method. Specimens of lung tissue were examined with an electron microscope, and the incidence of 13 types of pathological changes in the alveolar septum was studied. For each type of pathological change, the incidence was correlated with the magnitude of lung water content. The following results were obtained. The incidence of edematous changes in the alveolar interstitium (widening of the interstitial space, and dispersion and disarray of collagen fibres in the interstitial space) was well correlated with lung water content (r=0.78, p<0.01, and r=0.84, pc0.0 1, respectively). The correlation was not significant in the remaining types of changes. We conclude that the incidence of the pathological changes in the alveolar septum is increased along with the increase in the content of lung water in both dextran- and alloxaninduced experimental pulmonary edema in dogs.