Browsing by Subject "Psychosis"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Open Access
    Esquizofrenia y Musicoterapia
    (Universidad de Zaragoza, Asociación Universitaria de Formación del Profesorado (AUFOP), 1996) Loroño, Aittor
    El presente trabajo pretende ofrecer una experiencia de Musicoterapia realizada en el marco de un Centro de Salud Mental. La Musicoterapia está incluída dentro de las actividades que realizan los pacientes del Hospital de día. El trabajo resume la actividad desarrollada en dos grupos de pacientes durante un ario, desarrollando el encuadre de la experiencia, características de los pacientes, la metodología empleada y valoraci6n de lo que ha supuesto la inclusi6n de la Musicoterapia en un equipo terapéutico multidisciplinar. La experiencia es ŭnica en el Estado Español dentro de la sanidad p ŭblica.
  • Thumbnail Image
    Publication
    Open Access
    Women with psychotic episodes during pregnancy show increased markers of placental damage with Tenney-Parker changes
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2023) Ortega, Miguel A.; Fraile Martínez, Oscar; García Montero, Cielo; Rodriguez Martín, Sonia; Funes Moñux, Rosa M.; Pekarek, Leonel; Bravo, Coral; Leon Luis, Juan A. De; Saez, Miguel A.; Guijarro, Luis G.; Lahera, Guillermo; Monserrat, Jorge; Rodriguez Jimenez, Roberto; Saz, Jose V.; Buján, Julia; García Honduvilla, Natalio; Álvarez Mon, Melchor; Alvarez Mon, Miguel Angel
    y. Psychosis is a hazardous and functionally disruptive psychiatric condition which may affect women in pregnancy, entailing negative consequences for maternofetal well-being. The precise pathophysiological basis and consequences of a psychotic episode in pregnancy remain to be further elucidated. The placenta is a pivotal tissue with many functions in the gestational period, critically influencing the fate and development of pregnancy. Although detrimental alterations have been observed in women undergoing severe psychiatric disorders in pregnancy, there are little studies evaluating the consequences of suffering from a psychotic episode in the placental tissue In this work, we have evaluated the histopathological consequences of a first episode of psychosis in pregnancy (FE-PW; N=22) and compare them with healthy pregnant women (HC-PW; N=20) by using histological, immunohistochemical and gene expression techniques. Our results define that the placental tissue of FE-PW display an increase in the number of placental villi, bridges, syncytial knots and syncytial knots/villi. Besides, we have also observed an enhanced gene and protein expression in FE-PW of the hypoxic marker HIF-1α, together with the apoptotic markers BAX and Bcl-2. To our knowledge, this is the first study demonstrating significant histopathological changes in the placenta of women suffering a new-onset psychotic episode in pregnancy. Further studies should be aimed at deepening the knowledge about the pernicious effects of psychosis in the maternofetal tissues, as well as the potential implications of these alterations.