Browsing by Subject "Propionibacterium acnes"

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    An ultrastructural examination of murine alveolar macrophages following intranasal administration of Propionibacterium acnes
    (Murcia : F. Hernández, 1987) Hightower, James A.; Welsh, Marcia G.; Jackson, R.A.; Gangemi, J. David
    Light and electron microscopic analysis of murine lungs or isolated pulmonary cells was performed three days after intranasal administration of the bacterial immunostimulant, Propionibacterium acnes (P. acnes). Our observations indicated that pulmonary alveolar and airway macrophages (PAMs) were the only cells with P. acnes bacilli in their cytoplasm. Bacilli were not observed in pulmonary interstitial macrophages, granulocytes, lymphocytes or pulmonary parenchyma1 cells such as type I and type I1 pneumocytes. Because of the morphological heterogeneity of PAMs observed in control and experimental animals, it was not possible from these studies to be certain about the relative abundance or complexity of lysosomes, endoplasmic reticulum, Golgi and other organelles in the two groups. However, we noted that it was not uncommon to observe in the same PAM, profiles of P. acnes and a well developed Golgi complex and endoplasmic reticulum. These P. acnes - associated morphological alterations occurred at a time when functional activities (e.g., phagocytosis, cytostasis) of PAMs were enhanced.
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    Endocarditis caused by anaerobic bacteria
    (Elsevier, 2017-04-05) Kestler, M.; Muñoz, P.; Marín, M.; Goenaga, M.A.; Idígoras Viedma, P.; Alarcón, A. de; Lepe, J.A.; Sousa Regueiro, D.; Bravo-Ferrer, J.M.; Pajarón, M.; Costas, C.; García-López, M.V.; Hidalgo-Tenorio, C.; Moreno, M.; Bouza, E.; García-Vázquez, Elisa; Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en España (GAMES); Medicina
    Background Infective endocarditis (IE) caused by anaerobic bacteria is a rare and poorly characterized disease. Most data reported in the literature are from case reports [1–3]. Therefore, we assessed the situation of anaerobic IE (AIE) in Spain using the database of the Spanish Collaboration on Endocarditis (GAMES). Methods We performed a prospective study from 2008 to 2016 in 26 Spanish centers. We included 2491 consecutive cases of definite IE (Duke criteria). Results Anaerobic bacteria caused 22 cases (0.9%) of definite IE. Median age was 66 years (IQR, 56–73), and 19 (86.4%) patients were men. Most patients (14 [63.6%]) had prosthetic valve IE and all episodes were left-sided: aortic valves, 12 (54.5%); and mitral valves, 8 (36.4%). The most common pathogens were Propionibacterium acnes (14 [63.6%]), Lactobacillus spp (3 [13.63%]), and Clostridium spp. (2 [9.0%]), and the infection was mainly odontogenic. Fifteen of the 22 patients (68.2%) underwent cardiac surgery. Mortality was 18.2% during admission and 5.5% after 1 year of follow-up. When patients with AIE were compared with the rest of the cohort, we found that although those with AIE had a similar age and Charlson comorbidity index, they were more likely to have community-acquired IE (86.4% vs. 60.9%, p = 0.01), have undergone cardiac surgery (68.2% vs 48.7% p = 0.06), and have had lower mortality rates during admission (18.2% vs. 27.3%). Conclusion IE due to anaerobic bacteria is an uncommon disease that affects mainly prosthetic valves and frequently requires surgery. Otherwise, there are no major differences between AIE and IE caused by other microorganisms.