Browsing by Subject "Preeclampsia"

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    Hígado graso asociado a disfunción metabólica como factor de riesgopara preeclampsia en gestantes
    (Universidad de Murcia : servicio de publicaciones, 2026) Carnero Cabrera, Yohanna Xiomara; Yupari-Azabache, Irma Luz; Sin departamento asociado
    Introduction: Fatty liver disease associated with metabolic dysfunction is an obstetric emergency thatcan lead to maternal and foetal complications, including death.Objective: The present investigation aimed to analyze whether fatty liver associated with metabolicdysfunction is a risk factor for preeclampsia in pregnant women in a level III hospital in Trujillo - Peru.Method:Descriptive study type, quantitative approach and non-experimental, observational, analytical etrospective, case-control design. Using a data collection form, data related to the variables analyzed in 404 pregnant women were collected. They were then analyzed with the software spss version 26, the ORand confidence intervals were calculated.Results: The results show that pregnant women with preeclampsia and MAFLD come from urban areas,higher education level, marital status cohabiting/married, multi-pregnancy, do not have the minimumnumber of prenatal check-ups, are obese, do not have type II diabetes mellitus or dyslipidemia. Theprevalence of MAFLD in this population of pregnant women is low.Conclusions:Fatty liver associated with metabolic dysfunction is a risk factor for preeclampsia in pregnant women.
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    Histological villous maturation in placentas of complicated pregnancies
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2020) Vangrieken, Philippe; Vanterpool, Sizzle F.; Schooten, Frederik J. van; Nasiry, Salwan Al; Andriessen, Peter; Degreef, Ellen; Alfer, Joachim; Kramer, Boris W.; Rango, Ulrike von
    Chorioamnionitis and preeclampsia account for the majority of preterm births worldwide. Thus far, adequate methods for early detection or prevention of these diseases are lacking. In preeclampsia, accelerated villous maturation is believed to compensate placental insufficiency. However, little is known about the effects of placental inflammation in chorioamnionitis on villous maturation. Therefore, we established a set of morphological parameters to evaluate histological villous maturity in pregnancies complicated by chorioamnionitis and preeclampsia. Preterm placentas complicated by chorioamnionitis or preeclampsia were compared to idiopathic preterm placentas and term controls. Histological villous maturation was analyzed by means of 17 histological markers. Fourteen of these markers provided information on absolute and relative numbers of the terminal villi (TV), the extent of their vascularization (using CD31-stained sections) and their exchange capacity. In addition, the numbers of syncytial bridges, syncytial apoptotic knots and shed syncytiotrophoblasts were counted. Accelerated villous maturation in preeclampsia was demonstrated by means of histological villous remodeling and confirmed by 11 relevant markers. Chorioamnionitis, however, only showed increased area of fetal capillaries. In preeclampsia, placentas may transition from growth to maturation earlier than placentas in normal pregnancies, whereas in chorioamnionitis placental changes are more acute and therefore less elaborated at a structural level. Regression analysis suggests the number of all villi and the number of terminal villi as a percentage of all villi as parameters to evaluate histological villous maturity in preeclamptic placentas and to assist diagnosis. However, we would recommend to analyze all 11 relevant parameters to judge placental maturity in detail.
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    Increased immunohistochemical expression of thrombomodulin at placental perivascular myofibroblast in severe preeclampsia (PE)
    (Murcia : F. Hernández, 2005) Bosco, C.; Parra, M.; Barja, P.; Rodrigo, R.; Fernández, V.; Suarez, M.; Muñoz, H.
    The presence of pro-coagulant and anticoagulant components of the placental vascular endothelium and syncytiotrophoblast are essential for homeostasis. Vascular endothelium prevents blood clot formation in vivo by involving a cell surface thrombinbinding glycoprotein, thrombomodulin (TM), that activates plasma anti-coagulant protein C. The TM levels increase during pregnancy, but the fibrinolytic capacity diminishes. Since vascular lesions with placental coagulation disorders can be associated with preeclampsia (PE), we hypothesized that TM expression in the stem villous vasculature and syncytiotrophoblast of the placenta are impaired in PE. Plasma and placental tissue samples were collected from PE (n=12) and normotensive pregnant patients (n=11). Patient’s gestational age was 35.7±1.2 (normotensive) and 30.6±1.5 weeks (PE). Blood samples were drawn 30 min before delivery. Serum PAI-1 and PAI-2 antigens were determined by enzyme-linked immunoabsorbent assay (ELISA). A monoclonal antibody specific for TM was used for immunohistochemical tissue staining (ABC) and the staining was quantified by semi quantitative scores. Results show no intensity differences at the apical syncytiotrophoblast between the two groups. However, in preeclamptic placenta, TM expression diminished in the endothelium of the stem villi arteries and increased in the perivascular and stromal myofibroblats in cases of severe PE. TM changes were associated with an increased PAI-1/PAI-2 ratio. It is suggested that in severe PE, the decreased placental blood flow may be due to structural and functional impairment of the endothelium of the stem villi vessels and the surrounding perivascular and stromal myofibroblast, by increasing TM expression which may modulate fetal blow flow in the villous tree.
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    Pravastatin reduces plasma levels of extracellular vesicles in pregnancies at high risk of term preeclampsia
    (Frontiers Media, 2023-06-22) Santoyo, Jean Michell; Paco-Matallana, Catalina de; Delgado, Juan Luis; Cuevas, Santiago; Llinás Más, María Teresa; Hernández, Isabel; Avilés Plaza, Francisco Valeriano; Hernández Caselles, Trinidad; Noguera Velasco, José Antonio; Fisiología
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    Trophoblast-derived proteins and their effects on the pathogenesis of preeclampsia
    (Editum, 2026) Yanan Wang; Xueling Chen; Haifeng Zhang; Yunshan Xue; Haibin Chen; Ju Yang; Biología Celular e Histología
    Trophoblast cells are crucial structural units of the placenta, responsible for maintaining its integrity and function. These cells synthesize and secrete specific proteins that play essential roles in placental vascularization, maternal and fetal immune tolerance, and other critical processes. An abnormal level of trophoblast-derived secreted proteins has been closely linked to pregnancy-related diseases. Preeclampsia, a severe complication of pregnancy characterized by de-novo development of hypertension and proteinuria after 20 weeks of gestation, poses significant health risks to both the mother and fetus. This article reviews several key trophoblast-derived proteins that are widely recognized for their roles in preeclampsia. The specific mechanisms of action and interconnections among these proteins in preeclampsia are discussed, along with novel insights into the underlying pathological mechanisms of this disease.