Browsing by Subject "Polymorphism"

Now showing 1 - 3 of 3
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    Association between interleukin-10 gene polymorphisms and risk of oral carcinoma: A meta-analysis
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2020) Li, Fan; Xu, Xing; Xuan, Chao; Chen, Wan-Tao
    Background. The single nucleotide polymorphisms (SNPs) of Interleukin-10 (IL-10) gene have been linked with the risk of oral carcinoma (OC) in a relatively small sample size. Our study aims to investigate the pooled associations by conducting a meta-analysis of published studies. Methods. PubMed, Web of Science and Google Scholar databases were searched to identify eligible studies published in English before October 2019. The odds ratio (OR) with a 95% confidence interval (CI) was used to assess association. The publication bias was detected by Begg's test. Sensitivity and cumulative analyses were performed to evaluate the stability of crude results. Results. The meta-analysis involved eight studies. Significant associations were certified between IL-10 gene -1082A/G polymorphism and susceptibility of OC for A vs. G (OR=1.817, 95% CI: 1.481-2.230), AA vs. GG (OR=3.436, 95% CI: 2.281-5.175), dominant genetic model (OR=2.913, 95% CI: 1.939-4.376), and recessive genetic model (OR=1.886, 95% CI: 1.372- 2.594) in overall population, East Asians and South Asians. In addition, the significant association between - 592A/C polymorphism of the gene and susceptibility of OC were detected in South Asians. Conclusions. The meta-analysis results support that the IL-10 gene -1082G allele is a risk factor for OC in East Asians and South Asians, and IL-10 gene -592C allele is a protective factor for the disease.
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    NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases
    (Murcia: F. Hernández, 2007) Sun, X-F.; Zhang, H.
    Nuclear factor-kB (NF-kB) is responsible for the expression by regulating many genes for immune response, cell adhesion, differentiation, proliferation, angiogenesis and apoptosis. The function of NF-kB is inhibited by binding to NF-kB inhibitor (IkB), and imbalance of NF-kB and IkB has been associated with development of many diseases, including tumours. In this review, we focus on polymorphisms of the NFKB and NFKBI genes in relation to development of common inflammatory diseases including ulcerative colitis (UC), Crohn’s disease (CD), rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson’s disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer (CRC), hepatocellular carcinoma, breast cancer and myeloma.
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    Thrombocytopenia in leukemia: Pathogenesis and prognosis
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Shahrabi, Saeid; Maleki Behzad, Masumeh; Jaseb, Kaveh; Saki, Najmaldin
    Leukemias, a heterogeneous group of hematological disorders, are characterized by ineffective hematopoiesis and morphologic abnormalities of hematopoietic cells. Thrombocytopenia is a common problem among leukemia types that can lead to hemorrhagic complications in patients. The purpose of this review article is to identify the conditions associated with the incidence of thrombocytopenia in leukemias. It can be stated that although translocations have been considered responsible for this complication in many studies, other factors such as bone marrow failure, genes polymorphism, a mutation in some transcription factors, and the adverse effects of treatment could be associated with pathogenesis and poor prognosis of thrombocytopenia in leukemias. Considering the importance of thrombocytopenia in leukemias, it is hoped that the recognition of risk factors increasing the incidence of this complication in leukemic patients would be useful for prevention and treatment of this disorder.