Browsing by Subject "Paracetamol"

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    Cytototoxic effects of paracetamol (acetaminophen) in Allium cepa L. meristematic cells and seed germination
    (Universidad de Murcia. Servicio de publicaciones, 2025) Ortiz Molina, Gisele; Gouvea Buchweitz, Jéssica; Aguiar, Rosiane Borba de
    El desecho de medicamentos en la basura doméstica puede ser muy peligrosa para el medio ambiente. El presente trabajo buscó evaluar parámetros de toxicidad del contaminante emergente paracetamol. En los ensayos se utilizaron tres dosis de paracetamol (0,4 mg L-1, 0,5 mg L-1 y 0,6 mg L-1). Los resultados mostraron que la exposición aguda al paracetamol induce varios daños clastogénicos y aneugénicos en el test de A. cepa. No se encontró ningún efecto en la germinación. Aunque el paracetamol es un fármaco importante, también puede representar un riesgo significativo para la producción agrícola y la preservación del medio ambiente. Los resultados del presente trabajo corroboran datos anteriores y refuerzan que la exposición a contaminantes farmacéuticos puede representar un problema significativo para la producción de alimentos, el equilibrio ambiental y la preservación de especies.
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    Is maternal use of Paracetamol during pregnancy associated with anogenital distance in male newborns? The results from the NELA Birth Cohort
    (MDPI, 2021-06-11) Navarro Lafuente, Fuensanta; Arense Gonzalo, Julián Jesús; Adoamnei, Evdochia; Prieto Sánchez, María Teresa; Sánchez Ferrer, María Luisa; García-Marcos Álvarez, Luis Vicente; Morales Bartolomé, Eva; Mendiola Olivares, Jaime; Torres Cantero, Alberto Manuel; Ciencias Sociosanitarias
    Paracetamol is the one of the most commonly used medications during pregnancy. However, its potential antiandrogenic effect has been suggested. The objective of this study was to evaluate associations between maternal paracetamol use during pregnancy and anogenital distance (AGD) in male newborns from a Spanish birth cohort. The study included two hundred and seventy-seven mother-male child pairs with self-reported paracetamol use and frequency during each trimester of pregnancy. AGD measurements were taken employing standardized methods. The associations between maternal paracetamol use and AGD measures were evaluated using linear regression models, adjusting for potential confounders and covariates. Overall, 61.7% of pregnant women consumed paracetamol at any time of pregnancy with an average of 9.43 (SD = 15.33) days throughout pregnancy. No associations between the maternal use of paracetamol or its frequency and AGD measures among different trimesters or during the whole pregnancy were found in the adjusted final models. A non-differential misclassification error may have occurred—the recall of paracetamol intake independent of AGD measurements—introducing bias towards the null hypothesis. Nevertheless, the current evidence suggests that paracetamol might have a potential antiandrogenic effect especially in the early stages of fetal development. Thus, it would be highly recommendable to pursue further studies to elucidate the potential effects of paracetamol in human perinatal health and its use among pregnant women.