Browsing by Subject "Neurodevelopment"

Now showing 1 - 5 of 5
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    Child head circumference and placental MFSD2a expression are associated to the level of MFSD2a in maternal blood during pregnancy
    (Frontiers Media, 2020-02-05) Sánchez-Campillo, María; Ruiz-Palacios, María; Ruiz Alcaraz, Antonio José; Blanco Carnero, José Eliseo; Prieto Sánchez, María Teresa; Zornoza, Matilde; Ruiz-Pastor, María José; Demmelmair, Hans; Sánchez-Solís de Querol, Manuel; Koletzko, Berthold; Larqué Daza, Elvira; Bioquímica y Biología Molecular B e Inmunología; Facultad de Biología
    Gestational diabetes mellitus (GDM) is a world-wide health challenge, which prevalence is expected to increase in parallel to the epidemic of obesity. Children born from GDM mothers have lower levels of docosahexaenoic acid (DHA) in cord blood, which might influence their neurodevelopment. Recently, the membrane transporter Major Family Super Domain 2a (MFSD2a) was associated with the selective transportation of DHA as lysophospholipids. The expression of the DHA membrane transporter MFSD2a is lower in GDM placentas, which could affect materno-fetal DHA transport. Humans with homozygous inactivating mutations in the MFSD2a gene present severe microcephalyand intellectual impairments. Herein, we intended to identify early blood biomarkers that maybeofuse during pregnancy to monitor the offspring development and the adequate nutritional interventions, such as nutritional supplementation, that may be selected to improve it. We evaluated MFSD2a expression in maternal blood at the third trimester of pregnancy, and its potential relationship with the expression of placental MFSD2a at delivery and child outcomes. Three groups of pregnant women were recruited: 25 controls, 23 GDM with dietary treatment, and 20 GDM with insulin treatment. Maternal and neonatal anthropometric and biochemical parameters were evaluated. MFSD2a was analyzed in placenta, blood and serum. MFSD2a protein expression in maternal blood was significantly lower in GDM groups and correlated with placental MFSD2a and Z-score neonatal head circumference during the first 6 months of life. The cord/maternal serum ratio of DHA, a solid indicator of materno-fetal DHA transport, was reduced in GDMgroups and correlated with MFSD2a in maternal blood at the third trimester and in placenta at delivery. This indicates that altered MFSD2a levels in maternal blood during pregnancy might influence placental nutrient transport and fetal neurodevelopment. Furthermore, MFSD2a levels in maternal blood on the third trimester were inversely correlated to DHA in maternal serum lyso-PL. Thus, the level of MFSD2a in maternal blood could be used as a potential biomarker for the early detection of disturbances of MFSD2a expression during pregnancy and the subsequent consequences for the neurodevelopment of the child, as well as it may help to choose the optimal treatment approach for the affected subjects.
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    Guía clínica del TEAF en Atención Primaria
    (Red de Unidades de Salud Medioambiental Pediátrica; CMS-Asociación Española de Pediatría (AEP), Madrid, 2024) Campillo-López F.; Ortiz C.; Codina-Sampera E.; SánchezSauco MF.; Ortega García, Juan Antonio; Juan Antonio Ortega García; Cirugía, Pediatría y Obstetricia y Ginecología; Juan Antonio Ortega García; Facultades de la UMU::Facultad de Medicina
    Guía clínica de manejo y abordaje del TEAF para Atención Primaria es un documento técnico orientado a la detección precoz, cribado, seguimiento y coordinación asistencial del Trastorno del Espectro Alcohólico Fetal (TEAF) en el ámbito de la Atención Primaria. La guía integra criterios prácticos de evaluación del riesgo prenatal, identificación clínica, derivación y apoyo a familias y cuidadores, con un enfoque multidisciplinar centrado en la salud infantil y el neurodesarrollo. Además de su aplicación profesional, constituye un recurso útil para la formación universitaria y la docencia de grado y posgrado en Pediatría, Atención Primaria, salud medioambiental y prevención de trastornos del neurodesarrollo, al facilitar la enseñanza de algoritmos clínicos, itinerarios asistenciales y estrategias de intervención precoz. La guía incorpora materiales derivados de Órbita TEAF (libro) y se concibe como herramienta de apoyo tanto para la práctica clínica como para la capacitación de estudiantes y profesionales sanitarios
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    Ion channels and actin: A tale of two friends
    (Universidad de Murcia, Departamento de Histología e Histopatología, 2025) Sesti Federico; Forzisi Elena; Biología Celular e Histología
    An increasing number of studies highlight ion channels as multifunctional proteins involved in diverse cellular processes, including proliferation, differentiation, adhesion, migration, morphology, and programmed cell death (apoptosis). Given these broad roles, it is not surprising that ion channels interact closely with actin, a ubiquitous cytoskeletal component that participates in a vast array of biological functions. Ion channels depend on the actin cytoskeleton for essential activities such as trafficking to and from the plasma membrane. Conversely, actin dynamics are often modulated by ion channels during various cellular events. In this review, we provide an overview of the field and discuss key examples that reveal emerging patterns in the bidirectional interactions between ion channels and the actin cytoskeleton
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    Is low docosahexaenoic acid associated with disturbed rhythms and neurodevelopment in offsprings of diabetic mothers?
    ( Springer Nature , 2014-06-11) Zorzona Moreno, M.; Fuentes Hernández, S.; Carrión, V.; Alcántara López, María Vicenta; López Soler, Concepción; Larqué Daza, Elvira; Madrid Pérez, Juan Antonio; Sánchez-Solís de Querol, Manuel; Personalidad, Evaluación y Tratamiento Psicológicos; Facultades de la UMU::Facultad de Psicología y Logopedia
    BACKGROUND/OBJECTIVE: To evaluate the relation between docosahexaenoic acid (DHA) status and neurodevelopment in the offsprings of gestational diabetic mothers (ODMs). SUBJECTS/METHODS: A prospective cohort study was performed. The offspring of 63 pregnant women (23 controls, 21 diet-controlled gestational diabetes mellitus (GDM) and 19 insulin-treated GDM) were recruited. Maternal and venous cord plasma DHA percentages were analyzed. Skin temperature and activity in children were recorded for 72 h at 3 and 6 months of life. Neurodevelopment was assessed using the Bayley Scale of Infant Development II (BSID II) at 6 and 12 months of age. RESULTS: Cord plasma DHA percentage was significantly lower in the ODMs compared with that in the controls (Control 6.43 [5.04–7.82]a; GDM+diet 5.65 [4.44–6.86]ab; GDM+insulin 5.53 [4.45–6.61]b). Both mental (Control 102.71 [97.61–107.81]a; GDM+diet100.39 [91.43–109.35]a; GDM+insulin 93.94 [88.31–99.57]b) and psychomotor (Control 91.52 [81.82–101.22]a; GDM+diet 81.67[73.95–89.39]b; GDM+insulin 81.89 [71.96–91.85]b) scores evaluated by the BSID II were significantly lower at 6 months in ODMs, even after adjusting for confounding factors such as breastfeeding, maternal educational level and gender. Cord plasma DHA percentage correlated with the psychomotor score from BSID II (r = 0.27; P = 0.049) and with the intra-daily variability in activity (r = − 0.24; P = 0.043) at 6 months. Maternal DHA was correlated with several sleep rhythm maturation parameters at 6 months. CONCLUSIONS: Lower DHA levels in cord plasma of ODMs could affect their neurodevelopment. Maternal DHA status was also associated with higher values in the sleep rhythm maturation parameters of children.
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    Plexin-mediated neuronal development and neuroinflammatory responses in the nervous system
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2023) Dai, Lu; Shen, Kai-Feng; Zhang, Chun-Qing
    Plexins are a large family of single-pass transmembrane proteins that mediate semaphorin signaling in multiple systems. Plexins were originally characterized for their role modulating cytoskeletal activity to regulate axon guidance during nervous system development. Thereafter, different semaphorin-plexin complexes were identified in the nervous system that have diverse functions in neurons, astrocytes, glia, oligodendrocytes, and brain derived-tumor cells, providing unexpected but meaningful insights into the biological activities of this protein family. Here, we review the overall structure and relevant downstream signaling cascades of plexins. We consider the current knowledge regarding the function of semaphorin-plexin cascades in the nervous system, including the most recent data regarding their roles in neuronal development, neuroinflammation, and glioma.