Browsing by Subject "Modulation"

Now showing 1 - 4 of 4
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    Estradiol-mediated modulation of memory and of the underlying dendritic spine plasticity through the life span
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2024) González Burgos, Ignacio; Velázquez Zamora, Dulce A.; González Tapia, David
    The morphophysiology of the nervous system changes and adapts in response to external environmental inputs and the experiences of individuals throughout their lives. Other changes in the organisms internal environment can also contribute to nervous system restructuring in the form of plastic changes that underlie its capacity to adapt to emerging psycho-physiological conditions. These adaptive processes lead to subtle modifications of the organisms internal homeostasis which is closely related with the activity of chemical messengers, such as neurotransmitters and hormones. Hormones reach the brain through the bloodstream, where they activate specific receptors through which certain biochemical, physiological, and morphological changes take place in numerous regions. Fetal development, infancy, puberty, and adulthood are all periods of substantial hormone-mediated brain remodeling in both males and females. Adulthood, specifically, is associated with a broad range of life events, including reproductive cycles in both sexes, and pregnancy and menopause in women. Events of this kind occur concomitantly with eventual modifications in behavioral performance and, especially, in cognitive abilities like learning and memory that underlie, at least in part, plastic changes in the dendritic spines of the neuronal cells in cerebral areas involved in processing cognitive information. Estrogens form a family that consists of three molecules [17β-estradiol (E2), estrone, estriol] which are deeply involved in regulating numerous bodily functions in different stages of the life-cycle, including the modulation of cognitive performance. This review addresses the effects of E2 on the dendritic spine-mediated synaptic organization of cognitive performance throughout the life span.
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    Evaluation of the antibacterial and modulatory activities of ethanolic excract of Calotropis procera (Aiton) W.T. Aiton against multiresistant bacterial strains
    (Universidad de Murcia. Servicio de publicaciones, 2021) Santos Geraldo, Yuri; Garcia Leandro, Lívia María; Pereira Silva, Ana Raquel; Ferreira Campina, Fábia; Justino de Araújo, Ana Carolina; Ramos Freitas, Priscilla; Lucas dos Santos, Antonia Thassya; Esmeraldo Rocha, Janaina; Alencar de Menezes, Irwin Rose; Melo Coutinho, Henrique Douglas
    El objetivo de este estudio fue evaluar la actividad antibacteriana y moduladora del extracto etanólico de Calotropis procera (Aiton) W.T. Aiton contra cepas multirresistentes de bacterias. Por el método de microdilución, fueron definidas la concentración inhibidora mínima (MIC) del extracto y la modulación con la concentración inhibidora CIM / 8 del extracto con norfloxacina, gentamicina e imipenem contra Staphylococcus aureus, Escherichia coli y Pseudomonas aeruginosa. Se obtuvo 512 μg/mL para g/mL para Pseudomonas aeruginosa. Se descubrió sinergismo en el caso de Staphylococcus aureus, en la modulación con norfloxacina y gentamicina, mientras que con imipenem frente a Pseudomonas aeruginosa y con gentamicina para Escherichia coli. Con base en estos resultados, se necesitan más estudios para probar la actividad antibacteriana del extracto.
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    FAIR data for compunds included in the article "Modulating the catalytic activity by the mechanical bond: organocatalysis with polyamide [2]rotaxanes bearing a secondary amino function at the thread"
    (Universidad de Murcia, 2022-04-06) Perez, Jesus de Maria; Alajarín, Mateo; Martínez Cuezva, Alberto; Berná Cánovas, José; Química Orgánica
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    Schubert, Juan Benet y la musica de la resignación.
    (Universidad de Murcia, Servicio de Publicaciones, 2019) Lascaux, Sandrine
    The literature of Juan Benet attempts to transport the reader beyond the bounds of reason by means of the arts, and most especially in the relation that binds it to music. Following Schopenhauer and Nietzsche who considered music to be the only art capable of transmitting pure affect without any intellectual mediation, Benet seeks the limits of language and effects persistent sentence modulations with a view to accessing the music of the soul. In this respect, his essay Door of the Earth elucidates the close affliation between his work and the “music of resignation” which defnes Schubert’s later work.