Browsing by Subject "Menstrual cycle"
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- PublicationOpen AccessAcute pre-learning stress and declarative memory: impact of sex, cortisol response and menstrual cycle phase(Elsevier, 2013-04-12) Espín López, Laura; Almela, Mercedes; Hidalgo, Vanesa; Villada, Carolina; Salvador, Alicia; Gómez Amor, Jesús; Anatomía Humana y Psicobiología; Facultades de la UMU::Facultad de Psicología y LogopediaThis study explores the influence of pre-learning stress on performance on declarative memory tasks in healthy young adults in relation to sex and menstrual cycle phase. The sample was composed of 119 students (32 men and 87 women) from 18 to 25 years of age. The women were tested in different hormonal stages (30 in follicular phase, 34 in luteal phase, and 23 using oral contraceptives). The participants were exposed to the Trier Social Stress Test (TSST) or a control condition. Afterwards, their memory performance was measured using a standardized memory test (Rey's Auditory Verbal Learning Test). In the control condition, all groups of women recalled more words than men, but these differences disappeared in the group exposed to TSST because men's performance on the memory test improved, but only to the level of women. In addition, our data suggest that in women the relationship between cortisol and memory can be modulated by sex hormone levels, since in luteal women a negative relationship was found between memory performance and peak cortisol level. These results confirm that sex differences need to be considered in the relationship between pre-learning stress and memory performance.
- PublicationRestrictedEffects of sex and menstrual cycle phase on cardiac response and alpha- amylase levels in psychosocial stress(Elsevier, 2019-01) Espín López, Laura; Villada, Carolina; Hidalgo, Vanesa; Salvador, Alicia; Anatomía Humana y Psicobiología; Facultades de la UMU::Facultad de Psicología y LogopediaThe impact of sex and the menstrual cycle phase on the autonomic response to psychosocial stress remains controversial. This study explored autonomic nervous system activity through salivary alpha-amylase, heart rate, and heart rate variability responses to the Trier Social Stress Test (TSST) in healthy young people. The sample was composed of 25 men, 26 women in the luteal phase, and 25 women in the follicular phase, from 18 to 25 years of age. Participants were exposed to the TSST or a control condition. The results indicate that women in their follicular phase showed a blunted alpha-amylase response to stress compared to men and women in the luteal phase. In addition, men showed higher sympatho-vagal activity in the stress condition compared to the two groups of women. These results confirm that sex and the menstrual cycle phase are potential modulators of autonomic nervous system reactivity to psychosocial stress.
- PublicationOpen AccessMenstrual Cycle and Sport: effects on the performance and metabolism of the athlete woman(2022) Giménez-Blasi, Nuria; Latorre, Jose Antonio; Martínez-Bebia, Manuel; Sáenz, Marina; Cantero, Leticia; López-Moro, Alejandro; Jimenez-Casquet, Maria Jose; Conde-Pipo, Javier; Mariscal-Arcas, Miguel; Tecnología de Alimentos, Nutrición y BromatologíaThere are difficulties planning female training. The aim of this meta-analysis work is to know results obtained in studies on the relationship between the menstrual cycle (MC), diet, metabolism and performance in sportswomen. This work began in January-2022 looking differences in performance depending on the MC phase; exclusion criteria after 2015, non-experimental articles with quality indexes >Q2. We finally worked on 11 articles. Perception of the majority of sportswomen is that MC does have an impact on sports performance, as they are affected both physically and psychologically depending on the MC phase. Participant characteristics, such as training history, may also contribute to the variety of responses observed in studies. MC phase where performance may be reduced is in the Early Follicular Phase and may improve in the other MC phases. The effects found maybe of most relevance to female athletes
- PublicationOpen AccessMid-luteal phase progesterone effects on vigilance tasks are modulated by women’s chronotype(Elsevier, 2022-03-12) Palmero Jara, Lucía Beatriz; Tortajada Gomariz, Miriam; Campoy Menéndez, Guillermo; Fuentes Melero, Luis José; Martínez Pérez, Víctor; Psicología Básica y MetodologíaBackground In this study we assessed the effects of progesterone on vigilance tasks that require sustained attention. In contrast to previous research, we differentiated two components of vigilance: the exogenous component, involved in monotonous and tedious tasks such as the Psychomotor Vigilance Task (PVT); and the endogenous component, involved in tasks that require cognitive control such as the Sustained Attention to Response Task (SART). Methods A sample of 32 female participants differing in extreme chronotypes were tested at their optimal and non-optimal time-of-day, as secretion of sex hormones follows biological rhythms. Ovulation tests that measure the presence of luteinizing hormone (LH) in urine were used to minimize methodological errors. Women of Morning-type or Evening-type chronotypes completed 4 experimental sessions of the two attentional tasks when they were in their follicular (low progesterone level) and mid-luteal (high progesterone level) phases, both in the morning (8:00 AM) and the evening (8:30 PM). Results Compared with the follicular phase, performance in the mid-luteal phase improved in the Morning-type participants and worsened in the Evening-type participants. This pattern of results was observed only when testing occurred at the optimal time-of-day and with both the PVT and the SART tasks. Conclusion These results suggest that the simultaneous presence of both progesterone and cortisol at 8:00 AM may explain the benefit observed in Morning-type females. In contrast, the low concentration of cortisol along with the reduced benefit of mid-luteal phase progesterone in the evening may account for the worsening in performance observed in Evening-type females.
- PublicationOpen AccessNew insights into the normal menstrual cycle-regulatory molecules(Murcia : F. Hernández, 2004) Sivridis, E.; Giatromanolaki, A.Although the growth and regression of the endometrium is primarily a function of the ovarian hormones, recent studies indicate a potential autocrine/paracrine role for regulatory molecules. Thus, growth factors, angiogenesis stimulating factors and proliferating cell markers are high in the proliferative phase endometrium contributing to its regeneration. At the same time, other proteins promote endometrial cell survival by preventing extracellular matrix degradation and apoptosis. As glandular proliferation persists in the early secretory phase of the menstrual cycle, the activity of some proteins stimulating growth remains unchanged, but declines significantly thereafter, shifting the balance between proliferation and apoptosis in favour of apoptosis. During this period, several other regulatory substances are expressed at high levels, suggesting a role in endometrial maturation. If, however, implantation of a fertilized ovum fails to take place, menstruation occurs probably as the result of matrix metalloprotinases which antagononizes the anti-degradation factors (inhibitors of metalloproteinases). This review examines the changing endometrial patterns of a normal menstrual cycle in relation to these regulatory molecules.
- PublicationOpen AccessRegulation of human endometrial transforming growth factor ß1 and ß3 isoforms through menstrual cycle and medroxyprogesterone acetate treatment(Murcia : F. Hernández, 2002) Reis, F.M.; Ribeiro, M.F.M.; Maia, A.L.; Spritzer, P.M.The progesterone-induced differentiation of endometrial tissue from proliferative into secretory and decidua seems to be modulated by locally produced hormones and cytokines. Transforming growth factor beta (TGFß), a cytokine produced by endometrial cells, has been shown to modulate endometrial cell proliferation in vitro. Our aim was to evaluate the effects of medroxyprogesterone acetate (MPA) and the influence of menstrual cycle on the expression of TGFß1 and TGFß3 in human endometrium in vivo. In a doubleblind, placebo-controlled trial, 46 healthy women with regular menstrual cycles received either MPA (10 mg/day) or placebo during 10 days. Endometrial and blood samples were collected 8-12 hours after the last MPA or placebo administration. Patients were classified into three groups according to biopsy dating and treatment: proliferative [tissue]/placebo, secretory [tissue]/placebo and secretory [tissue]/MPA. The immunohistochemical distribution of TGFß1 and TGFß1 mRNA was similar in all groups. Immunoreactive TGFß3 was present in the epithelium in 9.1% of proliferative samples, in 41.2% of secretory/placebo samples and in 87.5% of secretory/MPA samples (p=0.001). In the stroma, the frequency of TGFß3 staining was markedly increased after treatment with MPA (62.5%) compared to placebo (proliferative: 9.1%; secretory: 5.9%; p=0.005). The levels of TGFß3 mRNA increased during the secretory phase and were higher in the MPA-treated group, being directly correlated with morphological endometrial differentiation. It is concluded that MPA administration to healthy women increased TGFß3 but did not change TGFß1 gene and protein expression in the endometrium. This finding suggests that TGFß3 may be a local factor mediating progesterone- and progestogen-induced endometrial differentiation.