Browsing by Subject "MCFD2"

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    A review of ERGIC-53, Its structure, functions, regulation and relations with diseases
    (Murcia : F. Hernández, 2009) Yong Ci Zhang; Yuan Zhou; Chun Zheng Yang; Dong Sheng Xiong
    ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calciumdependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 mainly acts as a receptor of a limited number of glycoprotein and transports them from ER to ERGIC and Golgi, meanwhile it has a secondary glycoprotein quality control function. Recent research has revealed that UPR, heat shock and VIPL may regulate the expression of ERGIC-53. F5F8D, and some ER storage diseases have relationship with ERGIC-53.