Browsing by Subject "KIR2D"

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    CD28 and KIR2D receptors as sensors of the immune status in heart and liver transplantation
    (Elsevier, 2011-06-22) Blanco García, R. M.; López Álvarez, María R.; Garrido, I. P.; Salgado Cecilia, G.; Campillo, José Antonio; Bolarín, José Miguel; Muro, Manuel; García Alonso, A.M.; Martínez Sánchez, María V.; Peña Moral, J.M. de la; Pascual Figal, Domingo A.; Álvarez López, María Rocio; Miras, M.; Minguela, Alfredo; Legaz Pérez, Isabel; Ciencias Sociosanitarias
    Viral infections and cellular acute rejection (AR) condition immunosuppressive therapy and compromise the evolution of allografts. Immune monitoring can be useful for ascertaining rejection and for differentiating allo-reaction from activation induced by infections. This work analyzes the usefulness of monitoring the expression of CD28 and KIR2D receptors in peripheral blood T lymphocytes by flow cytometry, to ascertain the immune response in heart and liver transplant recipients. In both types of transplant, the up-regulation of CD28 in CD4+ lymphocytes in the periods of greatest AR frequency indicates an effective allo-response, whereas the post-transplantation emergence of circulating CD8+CD28− and CD8+CD28−KIR2D+ T cells correlates with better early clinical results. Cytomegalovirus (CMV) infection, but not hepatitis C virus (HCV) or other infections, abrogated both CD28 up-regulation and CD8+CD28−KIR2D+ T-cell expansion. Our results show that monitoring the expression of CD28 and KIR2D receptors on T lymphocytes might be considered as sensors of the immune status of heart and liver recipients.