Browsing by Subject "Interstitial pneumonia"

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    Rheumatoid nodule and combined pulmonary carcinoma: topographic correlations; a case report and review of the literature
    (Murcia: F. Hernández, 2011) Spina, Donatella; Ambrosio, Maria Raffaella; Rocca, Bruno Jim; Di Mari, Nicoletta; Onorati, Mónica; Luzzi, Luca; Monciatti, Irene; Tosi, Piero
    An association between rheumatoid arthritis (RA) and malignancies has been ascertained and patients with RA appear to be at higher risk of lymphoma and lung cancer. The higher risk of the latter malignancy may be related to rheumatoid interstitial lung disease and immunosuppressive therapies. Herein we illustrate the case of a 59-year-old male smoker affected by RA and treated with cortisone, methotrexate and TNF-α antagonists, who underwent right lower lobectomy for a nodular lesion. On microscopic examination, the lesion consisted of two distinct areas: a central area of fibrinoid necrosis, bordered by histiocytes in a palisaded arrangement, lymphocytes and a 0.4 cm thick peripheral area constituted by a combined small cell anaplastic carcinoma, adenocarcinoma and squamous cell carcinoma. The combination of three histotypes is very rare in such a small tumour. In our case, it may be hypothesized that synchronous, heterogeneous mutations occurred in different type of committed cells or in stem cells, due to the production of cytokines by RA nodule histiocytes and lymphocytes, which are contiguous to the carcinomatous area. Since few studies have evaluated the topographic correlation between tumors and rheumatoid lung lesions, further morphological and molecular studies are needed to clarify this association and the pathogenetic relationship between RA and cancer of the lung.
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    Unique expression profiles of mucin proteins in interstitial pneumonia-associated lung adenocarcinomas
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2019) Tateishi, Yoko; Kataoka, Toshiaki; Okudela, Koji; Nakashima, Yu; Mitsui, Hideaki; Matsumura, Mai; Umeda, Shigeaki; Arai, Hiromasa; Baba, Tomohisa; Suzuki, Takehisa; Koike, Chihiro; Tajiri, Michihiko; Takemura, Tamiko; Ogura, Takashi; Masuda, Munetaka; Ohashi, Kenichi
    In order to clarify idiopathic interstitial pneumonia (IIP)-associated lung adenocarcinoma (LADC), we herein focused on the expression profiles of mucin proteins, the most common cellular differentiation markers. The expression of the mucin (MUC) 1, MUC2, MUC3B, MUC4, MUC5AC, MUC5B, MUC6, MUC7, MUC9, and MUC21 proteins was examined immunohistochemically and their levels were semi- quantified in 80 IIP-associated LADCs and 106 non-IIP LADCs. LADCs were divided into low and high expressers based on thresholds obtained from the receiver operating characteristic (ROC) curves of each mucin protein. Low expressers of MUC1, MUC7, and MUC21 and high expressers of MUC4, MUC5AC, MUC5B, and MUC9 were dominant in the IIP group. Multivariate analyses confirmed that the correlations between mucin expression profiles and IIP-associated LADCs were independent of putative confounding factors, such as smoking, gender, histological types, and cytological types. Thus, the expression profiles of these mucin proteins significantly differed between the IIP and non-IIP groups. IIP-associated LADCs appear to have unique cellular differentiation features and they may develop through a distinct histogenetic pathway. This is the first study to demonstrate that IIP-associated LADCs have unique mucin expression profiles.