Browsing by Subject "Inserción"

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    B-learning para inducción del profesorado principiante. El caso del programa INDUCTIO en la República Dominicana
    (Universidad de Murcia, Servicio de Publicaciones, 2016) Marcelo, Carlos; Gallego-Domínguez, Carmen; Mayor, Cristina
    En este artículo describimos el caso de un programa de inducción dirigido al profesorado principiante en el que se utilizan de manera intensiva los recursos digitales (b-learning) con diferentes objetivos: creación de comunidades de aprendizaje, reflexión, análisis de la práctica, comunicación, y como consecuencia de ello, contribución al desarrollo profesional. El programa que describimos lo denominamos INDUCTIO (Programa de formación para la inducción del profesorado principiante de la República Dominicana). El programa de formación INDUCTIO se fundamenta en una visión constructivista y conectivista de la formación docente. Además asume los principios de la autoformación y el desarrollo profesional docente basado en la evidencia. Coherente con esta visión, el programa plantea un amplio conjunto de experiencias de aprendizaje que facilita en los docentes principiantes una inserción de calidad en la docencia. En el programa están participando activamente 363 profesores principiantes y 45 mentores. El programa ofrece herramientas tecnológicas para el apoyo al proceso de inducción como son el diario reflexivo, los planes de mejora, los foros, la plataforma de contenidos online, el portal de recursos educativos, los círculos de aprendizaje, etc.
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    Eight-membered Palladacycles Derived from the Insertion of Olefines into the Pd–C Bond of Ortho-palladated Pharmaceuticals Phenethylamine and Phentermine. Synthesis of Stable Heck-type Intermediates Containing Accessible β-Hydrogens and its Use in the Synthesis of 2-Styryl-phenethylamines, Tetrahydroisoquinolines and Eight-membered Cyclic Amidines
    (ACS, 2010-09-13) Vicente, José; Saura-Llamas, Isabel; García-López, José-Antonio; Bautista, Delia; Vicente, José; Química Inorgánica
    The ortho-metalated complexes derived from phenethylamine and phentermine [Pd(C,N-C6H4CH2CR2NH2-2)(μ-X)]2 (R = H, X = Br (A); R = Me, X = Cl (B)) react with olefins giving (1) the product of its insertion into the Pd–C bond, [Pd{C,NCH( R’)CH2C6H4CH2CR2NH2-2}(μ-X)]2 (olefin = CH2=CHR’; R = H, X = Cl, R’ = C(O)Me (1a), CO2Et (1c); R = Me, X = Cl, R’ = C(O)Me (1b), CO2Et (1d)), [Pd{C,NCH( C5H8)CHC6H4(CH2CMe2NH2)-2}(μ-Cl)]2 (olefin = norbornene, C5H8; 1e) or (2) the decomposition products of 1, i.e., Pd(0) and the complexes containing the arylated olefin, trans-[PdX2(NH2CR2CH2C6H4CH=CHPh-2)2] (olefin = styrene; R = H, X = Cl (3f); R = Me, X = Br (3g)). While complexes 1c and 1d can be isolated but decompose in solution to afford Pd(0) and the corresponding complexes 3 (R = H, X = Cl (3c); R = Me, X = Br (3d)), the others are surprisingly stable. Neutral ligands L cleave the bridge of complexes 1 to afford [Pd(C^N)X(L)] (2) (L = 4-methyl-pyridine (pic), NH3, NHEt2, PPh3, tBuNC, XyNC). Complexes 3 react with 1,10-phenanthroline (phen) to give [PdX2(phen)] and the orthovinylated arylalkylamine RCH=CHC6H4CH2CR2NH2-2 (R = H (4f), Me (4g)), which in the case of 3c or 3d can not be isolated as it undergoes an intramolecular hydroamination process to afford the tetrahydroisoquinoline 5c or 5d, respectively. To prepare the tetrahydroisoquinoline 5b, it is necessary to heat a mixture of complex 1b with one equiv of TlOTf. The eight-membered cyclic amidine 7d is obtained from thermal decomposition of complex cis-[Pd{C,N-CH(CO2Et)CH2C6H4CH2CR2NH2-2}(CNXy)2]OTf (8d), prepared by reaction of 2d-5 with TlOTf and XyNC. The amidinium salt 7e-HOTf is formed by refluxing in toluene a mixture of 2e-4 and TlOTf. The crystal structures of compounds 2a·CHCl3, 2b-1, 3 2d-3·1/3CH2Cl2, 2e-4·1/2CHCl3, 3d, 3g, 6 and 7e-HOTf have been determined by X-ray diffraction studies.
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    Reactivity toward CO of Eight-Membered Palladacycles Derived from the Insertion of Alkenes into the Pd–C Bond of Cyclopalladated Primary Arylalkylamines of Pharmaceutical Interest. Synthesis of Tetrahydrobenzazocinones, Ortho-Functionalized Phenethylamines, Ureas, and an Isocyanate
    (ACS, 2012-08-16) García-López, José-Antonio; Oliva-Madrid, María-José; Saura-Llamas, Isabel; Bautista, Delia; Vicente, José; Vicente, José; Química Inorgánica
    The ortho-metalated complex [Pd{C,N-C6H2CH2CH2NH2-2,(OMe)2-4,5}(μ-Br)]2 (1a) derived from homoveratrylamine reacts with ethyl acrylate, methyl vinyl ketone or 2-norbornene to give the dimeric complex arising from the insertion of the alkene into the Pd–C bond, [Pd{C,N-CH(R)CH2C6H2CH2CH2NH2-2,(OMe)2-4,5}(μ-Br)]2 (R = CO2Et (2a1), C(O)Me (2a2)) or [Pd{C,N-CH(C5H8)CHC6H2CH2CH2NH2-2,(OMe)2-4,5}(μ-Br)]2 (2a3). Complexes 2a and the phentermine homologues 2b react with CO to afford Pd(0) and (1) tetrahydrobenzazocinones, the heterocycles resulting from CO insertion into the Pd–C bond and C–N coupling, (2) unnatural aminoacid derivatives resulting from CO insertion and the reaction of the obtained acyl complex with the solvent (MeOH), or the product of protonolysis of the Pd–C bond, depending on the nature of the initial cyclopalladated compound or (3) ureas, alone or mixed with an isocyanate, in the presence of a base. Phentermine derivatives 2b react with HCl to give a dinuclear palladium complex [PdCl(μ- Cl)(L)], where L is the amine arising from the protonolysis of the Pd–C bond or the alkyl group resulting from Pd–N bond protonolysis, depending on the nature of the inserted alkene. The crystal structures of some palladium complexes and organic compounds have been determined by X-ray diffraction studies.