Browsing by Subject "Homeostasis"

Now showing 1 - 3 of 3
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    Neurorracionalidad y valor biológico
    (Universidad de Murcia, 2013) Conill Sancho, Jesús
    Este trabajo muesta la necesidad de ampliar la noción de la racionalidad práctica, a partir de la nueva perspectiva de las neurociencias y destacar el trasfondo valorativo de la racionalidad en cualquiera de sus versiones contando con las aportaciones del enfoque neurológico. Una racionalidad plural, radicada en el cuerpo y cuyo carácter vital está impregnado de valores, emociones y sentimientos.
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    The diverse functions of DYRK2 in response to cellular stress
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2024) Kawamura, Akira; Yoshida, Saishu; Yoshida, Kiyotsugu
    To maintain microenvironmental and cellular homeostasis, cells respond to multiple stresses by activating characteristic cellular mechanisms consisting of receptors, signal transducers, and effectors. Dysfunction of these mechanisms can trigger multiple human diseases as well as cancers. Dual-specificity tyrosine-regulated kinases (DYRKs) are members of the CMGC group and are evolutionarily conserved from yeast to mammals. Previous studies revealed that DYRK2 has important roles in the regulation of the cell cycle and survival in cancer cells. On the other hand, recent studies show that DYRK2 also exhibits significant functions in multiple cellular stress responses and in maintaining cellular homeostasis. Hence, the further elucidation of mechanisms underlying DYRK2’s diverse responses to various stresses helps to promote the advancement of innovative clinical therapies and pharmacological drugs. This review summarizes the molecular mechanisms of DYRK2, particularly focusing on cellular stress responses.
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    The role of chaperone-mediated autophagy in tissue homeostasis and disease pathogenesis.
    (MDPI, 2024-01-23) Martínez Vicente, Marta; Valdor Alonso, Rut; Bioquímica y Biología Molecular B e Inmunología