Browsing by Subject "Histogenesis"

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    lmmunomorphologica characteristics of renal cell carcinoma
    (Murcia : F. Hernández, 1995) Markovic-Lipkovski, J.; Brasanac, D.; Todorovic, V.; Múller, Gerhard Anton; Múller, Gerhard Anton
    Immunomorphological characteristics of 27 renal cell carcinoma (RCC): 18 clear cell, 6 granular (chromophilic), 2 chromophobe, 1 spindle cell (sarcomatoid) as well as of 1 oncocytoma, were analyzed. The investigation was performed on cryostat sections by immunoperoxidase technique applying a panel of monoclonal antibodies which defined: proximal (TNE3, TN5, 5D9) and distal (TN8, TN9, 7C2) tubular antigens; intercellular adhesion molecule 1 (ICAMl); HLA class I1 (-DQ, -DR and -DP) antigens, intermediary filaments (cytokeratin and vimentin); and antigens on tumour infiltrating mononuclear leucocytes (TT1, TT2 and LeuM3 for CD4, CD8 and CD14 antigens, respectively). All RCC with exception of chromophobe CO-expressed cytokeratin and vimentin. In addition, they were usually positive for all proximal and two distal tubular markers (TN8, TN9) indicating primitive cells which could differentiate into the epithelium of both parts of tubule system as the most probable originators of in RCC. Almost all RCC but the chromophobe aberrantly expressed HLA class I1 antigens which great variability from case to caie. The presence of HLA-DR antigens was more intensive and widespread than of HLA-DQ and-DP antigens. Expression of ICAMl mostly correlated with presence of HLA class I1 antigens, particularly with -DR on tumour cells of RCC HLA-DR antigen expression was always more prominent than mononuclear cell infiltrate (among which macrophages prevailed over T cells) which could suggest that increased histocompatibility antigen expression precedes mononuclear cell influx. In contrast to all other RCC, chromophobe tumours had quite distinct features revealing the most intense reaction with 7C2 (MAb that produced the weakest reaction with other tumour types), absence of vimentin and very weak reaction with antibodies for HLA class Il Ag and ICAM 1. Since oncocytoma has similar immunohistological properties it could be supposed that both tumours have common histogenesis.
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    Relationship between non-TRU lung adenocarcinomas and bronchiolar metaplasia - potential implication in their histogenesis -
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Okudela, Koji; Kojima, Yoko; Matsumura, Mai; Arai, Hiromasa; Umeda, Shigeaki; Tateishi, Yoko; Mitsui, Hideaki; Suzuki, Takehisa; Tajiri, Michihiko; Ogura, Takashi; Ohashi, Kenichi
    Lung adenocarcinomas (ADCs) have been roughly divided into two groups: the terminal respiratory unit (TRU) type and non-TRU type. These ADCs appear to develop through exclusive carcinogenetic pathways because of differences in their cellular morphologies and the profiles of protein expression and genetic alterations. The TRU type develops from atypical adenomatous hyperplasia as a precursor. On the other hand, the histogenesis of the non-TRU type has not yet been defined in detail. We herein investigated histopathological changes in the non-tumor lung tissues of patients with non-TRU-type ADCs in order to define their potential histogenesis. The non-TRU type preferentially occurs in patients with interstitial pneumonia, in whom tumors are located in honeycomb lesions and are associated with bronchiolar metaplasia (BM). Among patients without interstitial pneumonia, non-tumor lung tissues from non-TRU-type ADCs were often affected by multiple BM. In these cases, tumors often were associated with BM. Metaplastic cells adjacent to non-TRU-type ADCs ectopically expressed HNF-4α, a marker for non-TRU-type ADCs. These results suggest that the non-TRU type develops through distinct histogenesis, in which BM is implicated.
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    Unorthodox myogenesis, possi ble developmental significance and implications for tissue histogenesis and regeneration
    (Murcia : F. Hernández, 1997) Cossu, G.
    During the last few years several reports have described the occurrence of skeletal myogenesis in cells derived from embryonic, fetal and perinatal tissues that usually do not contribute to skeletal muscle in the adult vertebrate body. After a brief description of current ideas on myogenic determination in higher vertebrates, three examples of this unorthodox myogenesis will be described: 1) the occurrence of myogenesis in chick epiblast cells, cultured in isolation in serum-free medium; 2) the presence of cells endowed with myogenic potential in the embryonic mouse neural tube; and 3) the occurrence of spontaneous or induced myogenesis in mesenchymal cells during fetal and postnatal life. A possible embryological basis for unorthodox myogenesis, in relation to gastrulation and morphogenetic fields, is then presented. It is also proposed that unorthodox myogenesis may represent a compensatory mechanism for higher vertebrates that have lost much of the regeneration potential of lower vertebrates.