Browsing by Subject "HCM"

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    Concurrent resistance and cardiorespiratory training in patients with hypertrophic cardiomyopathy: a pilot study
    (MDPI, 2024-04-17) Bayonas-Ruiz, Adrián; Muñoz-Franco, Francisca M.; Sabater Molina, María; Martínez González-Moro, Ignacio; Gimeno Blanes, Juan Ramón; Bonacasa Fernández, Bárbara; Fisiología
    Background: Exercise training in patients with HCMhas evidenced benefits on functional capacity, cardiac function, and a reversion of adverse cardiac remodeling. The objective of this study was to assess the effect of a concurrent resistance and cardiorespiratory training program on functional capacity, biochemical parameters, and echocardiographic variables in a pilot group. Methods: Two HCMpatients were evaluated before and after 12 weeks of individualized concurrent training with two sessions/week. Pre- and post-training data were compared for each patient. Evaluations included a cardiopulmonary exercise test (CPET), body composition, echocardiography, electrocardiography, and blood analysis. Results: Training promoted an increase in functional capacity (+4 mL·kg−1·min−1), ventilatory thresholds, and other CPET-derived variables associated with a better prognosis and longterm survival. Muscular mass was augmented (0.8 and 1.2 kg), along with a mean increase of 62% in upper and lower body strength. Echocardiographic features demonstrated the maintenance of cardiac function with signs of positive left ventricular remodeling and an improvement in diastolic function. Blood analyses, including cardiac troponins and NT-proBNP, displayed uneven changes in each patient, but the values fell into normal ranges in both cases. Conclusions: The available data suggest a positive effect of concurrent resistance and cardiorespiratory training on patients’ functional capacity and cardiac function thatmay improve their functional class, quality of life, and long-termprognosis. The replication of this protocol in a larger cohort of patients is warranted to confirm these preliminary results.