Browsing by Subject "Etiology"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Publication
    Open Access
    Características físicas y psicomotoras, modalidades de tratamiento y escolarización en distintos tipos de parálisis cerebral infantil en la Región de Murcia
    (Universidad de Murcia, 1994) García-Sánchez, Francisco Alberto; Caballero, Presentación A.; Castellanos, Pilar
    En este estudio se han analizado las características físicas y psicomotoras de 48 niños con parálisis cerebral infantil de tipo hemipléjico, dipléjico, tetrapléjico e hipotónico, las modalidades de tratamiento recibidas en el Centro de Atención Temprana de ASTRAPACE (Murcia) y el tipo de escolarización alcanzado. Los resultados obtenidos apoyan conclusiones de estudios epidemiológicos previos y señalan la existencia de importantes diferencias en el perfil psicomotor de los distintos síndromes de parálisis cerebral.
  • Thumbnail Image
    Publication
    Open Access
    The pathogenesis and pathology of idiopathic pleuroparenchymal fibroelastosis
    (2021) Kinoshita, Yoshiaki; Ishii, Hiroshi; Nabeshima, Kazuki; Watanabe, Kentaro
    Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a rare subtype of idiopathic interstitial pneumonias that consists of elastofibrosis involving the lung parenchyma and pleural collagenous fibrosis predominantly located in the upper lobes. IPPFE has various distinct clinical and physiological characteristics, including platythorax and a marked decrease of forced vital capacity with an increased residual volume on a respiratory function test. The concept of IPPFE is now widely recognized and some diagnostic criteria have been proposed. In addition, the accumulation of cases has revealed the pathological features of IPPFE. However, little is known about the pathogenesis or the process of disease formation in IPPFE. This review article will provide a summary of the pathological features and previously reported hypotheses on disease formation in IPPFE, to discuss the potential etiologies and pathogenesis of IPPFE.
  • Thumbnail Image
    Publication
    Open Access
    The peritoneal macrophage inflammatory profile in cirrhosis depends on the alcoholic or hepatitis C viral etiology and is related to ERK phosphorylation.
    (BMC, 2012-08-06) Martínez-Pascual, Cristina; Miras-López, Manuel; Such, José; Francés, Rubén; García-Peñarrubia, Pilar; Hernández Caselles, Trinidad; Martínez-Esparza Alvargonzález, María Concepción; Ruiz Alcaraz, Antonio José; Tapia Abellán, Ana; Bioquímica y Biología Molecular B e Inmunología
    Background: The development of ascites in cirrhotic patients generally heralds a deterioration in their clinical status. A differential gene expression profile between alcohol- and hepatitis C virus (HCV)-related cirrhosis has been described from liver biopsies, especially those associated with innate immune responses. The aim of this work was to identify functional differences in the inflammatory profile of monocyte-derived macrophages from ascites in cirrhotic patients of different etiologies in an attempt to extrapolate studies from liver biopsies to immune cells in ascites. To this end 45 patients with cirrhosis and non-infected ascites, distributed according to disease etiology, HCV (n=15) or alcohol (n=30) were studied. Cytokines and the cell content in ascites were assessed by ELISA and flow cytometry, respectively. Cytokines and ERK phosphorylation in peritoneal monocyte-derived macrophages isolated and stimulated in vitro were also determined. Results: A different pattern of leukocyte migration to the peritoneal cavity and differences in the primed status of macrophages in cirrhosis were observed depending on the viral or alcoholic etiology. Whereas no differences in peripheral blood cell subpopulations could be observed, T lymphocyte, monocyte and polymorphonuclear cell populations in ascites were more abundant in the HCV than the alcohol etiology. HCV-related cirrhosis etiology was associated with a decreased inflammatory profile in ascites compared with the alcoholic etiology. Higher levels of IL-10 and lower levels of IL-6 and IL-12 were observed in ascitic fluid from the HCV group. Isolated peritoneal monocyte-derived macrophages maintained their primed status in vitro throughout the 24 h culture period. The level of ERK1/2 phosphorylation was higher in ALC peritoneal macrophages at baseline than in HCV patients, although the addition of LPS induced a greater increase in ERK1/2 phosphorylation in HCV than in ALC patients. Conclusions: The macrophage inflammatory status is higher in ascites of alcohol-related cirrhotic patients than in HCV-related patients, which could be related with differences in bacterial translocation episodes or regulatory T cell populations. These findings should contribute to identifying potential prognostic and/or therapeutic targets for chronic liver diseases of different etiology.