Browsing by Subject "Drug screening"

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    Fish tales: The use of zebrafish xenograft human cancer cell models
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2017) Drabsch, Yvette; Snaar Jagalska, Ewa; Ten Dijke, Peter
    Advances in scientific techniques have provided researchers with exceptional new opportunities to identify and monitor changes between different cancer types, during different stages of progression, between individual tumor cells and in the surrounding stroma. The wealth of information that can be obtained from new scientific techniques places additional requirements on the conventional cancer models. New models that could be used to rapidly access the (potential) functional importance of newly identified (epi)genetic and proteomic changes and test the efficacy on emerging (combinatorial) therapies are desperately required. The distinctive characteristics of zebrafish are progressively being applied to create more relevant models of human diseases. Zebrafish embryos provide a powerful tool to develop functional cancer models. This is a tool that can be used from drug discovery and development to assessment of drug toxicity. This review will summarise the use of zebrafish xenograft models to study human cancers, and discuss the benefits and limitations of these models.
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    Prospects of induced pluripotent stem cells in treating advancing Alzheimer’s disease: A review
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2025) Park, Juyoun Janis; Rim, Yeri Alice; Sohn, Yeowon; Nam, Yoojun; Ju, Ji Hyeon
    The World Health Organization has identified Alzheimer’s disease (AD), the leading cause of dementia globally, as a public health priority. However, the complex multifactorial pathology of AD means that its etiology remains incompletely understood. Despite being recognized a century ago, incomplete knowledge has hindered the development of effective treatments for AD. Recent scientific advancements, particularly in induced pluripotent stem cell (iPSC) technology, show great promise in elucidating the fundamental mechanisms of AD. iPSCs play a dual role in regenerating damaged cells for therapeutic purposes and creating disease models to understand AD pathology and aid in drug screening. Nevertheless, as an emerging field, iPSC technology requires further technological advancement to develop effective AD treatments in the future. Thus, this review summarizes recent advances in stem cell therapies, specifically iPSCs, aimed at understanding AD pathology and developing treatments