Browsing by Subject "Diseases"

Now showing 1 - 5 of 5
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    A surgical approach to root coverage and correction of mucogingival conditions and deformities in mandibular incisors with isolated gingival recession: free mucogingival graft. A pilot prospective cohort study
    (Quintessence Publishing Co Inc, 2024-03-20) Moreno Rodríguez, José Antonio; Ortiz Ruiz, Antonio José; Dermatología, Estomatología, Radiología y Medicina Física
    The aim of this study was to present a periodontal plastic surgery approach to treat gingival recessions (GRs) and correct mandibular incisor mucogingival conditions and deformities. Isolated deep GRs (≥ 3 mm) in the mandibular incisors (n = 24 teeth) were treated: 66.6% of sites were recession types 2 or 3, and 58.3% of teeth were malpositioned. Recessions were treated using free mucogingival grafts (FMGs) harvested from the buccal aspect of donor teeth with altered passive eruption or healthy periodontal support, with < 3 mm between the cementoenamel junction and the buccal alveolar crest. Clinical parameters (GR, clinical attachment level, interproximal papilla tip location, keratinized tissue, vestibule depth) and root coverage esthetic score were evaluated at 9 months. FMG significantly reduced GR (P < .001) and increased keratinized tissue (P < .001) without loss of vestibule depth (P > .05). Mean root coverage was 94.37% ± 10.60%, mean residual GR was 0.08 ± 0.65 mm, and the mean root coverage esthetic score was 8.9 ± 1.24. Recession types 2/3 showed significant interproximal clinical attachment gain (P < .05). The interproximal papilla was significantly augmented at sites with papilla loss (P < .001). No clinical attachment loss (P = .346) was detected at donor sites. These results suggest that FMG is a promising root coverage approach for recession types 1, 2, and 3, correcting mucogingival conditions and deformities and reconstructing the interproximal papilla.
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    Canine distemper virus may affect European wild cat populations in Central Spain
    (Elsevier GmbH, 2019-05-06) Candela, Mónica G.; Pardavila, Xosé; Lamosa, Adrián; Mangas, Julián G.; Martinez-Carrasco, Carlos; Ortega Hernández, Nieves; Sanidad Animal; Sorex Ecoloxía e Medio Ambiente S. L, Spain; Ecology Area, Department of Biology and Geology, Physics and Inorganic Chemistry, University Rey Juan Carlos, Madrid, Spain
    The main objective of this brief communication is to inform about the exposure to certain pathogens of interest for mesocarnivores in wildcats (Felis silvestris silvestris) that inhabit a human-domestic-wild ecotone located in a Natural Park (Serranía de Cuenca, Central Spain). Blood and mucosal swabs (nasal, conjunctival and rectal) samples were collected from nine alive animals to detect canine distemper virus (CDV), parvovirus (CPV/FPV), feline leukaemia virus (FeLV), feline coronavirus (FCoV), feline immunodeficiency virus (FIV), Leptospira interrogans, Chlamydia felis, Ehrlichia canis, Toxoplasma gondii, and Neospora caninum. ELISA, immunochromatograpy, microscopy agglutination test and PCR assays were used. The results show the first worldwide detection of exposure of wildcats to L. interrogans (3 positive/9 analysed) and the first detection of exposure to CVD (7/9), of carriers of C. felis (2/9) and of fecal spreading of CPV-FPV (2/9) in wildcats in Spain. Exposure to T. gondii and CPV-FPV was detected in 5 of the 9 wildcats analysed, and to FelV in 4 of 9. No FIV, FCoV, Ehrlichia canis and Neospora caninum were detected. The results reveal the circulation of pathogens among the wildcat population studied, but more vigilance is needed for an accurate assessment of the impact of these pathogens on the health status of this population.
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    La evolución de la mortalidad y causas de muerte en la diputación de El Beal (Murcia), 1880-1970.
    (Murcia : Editora Regional de Murcia, 2004) Navarro Ortíz, Domingo; Pérez de Perceval Verde, Miguel Ángel; Martínez Soto, Ángel Pascual; Editora Regional de Murcia
    Se analizan las modificaciones en la mortalidad en un núcleo minero ligado a la minería del plomo, que en este periodo se realiza por pequeñas sociedades mineras en una de las cuencas que han dado más producción en España, la Sierra de Cartagena-La Unión en Murcia. Estudiamos el proceso de transición demográfica, que se ve mediatizado por las especiales condiciones de la zona: alta mortalidad, especialmente infantil, donde influyen las especiales condiciones de trabajo (con una alto porcentaje de mano de obra infantil) y unas pésimas infraestructuras de vivienda y urbanas. Ello va a determinar una sobremortalidad, por encima de la media nacional y regional, además de una persistente morbilidad por causas infecciosas. Se analiza la progresiva modificación, que se ve interferida por la crisis de las explotaciones mineras de la comarca, pero que va permitiendo una modernización de las tasas vitales. En este aspecto señalamos las dificultades con las que nos hemos encontrado para la reconstrucción de unas tasas que permitan una comparación fiable con otros lugares en una comarca con unos elevados flujos migratorios.
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    Neurotoxins and pore forming toxins in sea anemones: Potential candidates for new drug development
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2023) Wang, Zhi-Lin; Zhang, Shu-Yi; Hao, Shuang Li; Yang, Wan Xi
    There are two kinds of toxins in sea anemones: neurotoxins and pore forming toxins. As a representative of the sodium channel toxin, the neurotoxin ATX II in neurotoxin mainly affects the process of action potential and the release of transmitter to affect the inactivation of the sodium channel. As the representatives of potassium channel toxins, BgK and ShK mainly affect the potassium channel current. EqTx and Sticholysins are representative of pore forming toxins, which can form specific ion channels in cell membranes and change the concentration of internal and external ions, eventually causing hemolytic effects. Based on the above mechanism, toxins such as ATX II can also cause toxic effects in tissues and organs such as heart, lung and muscle. As an applied aspect it was shown that sea anemone toxins often have strong toxic effects on tumor cells, induce cancer cells to enter the pathway of apoptosis, and can also bind to monoclonal antibodies or directly inhibit relevant channels for the treatment of autoimmune diseases.
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    Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Oral, Ozlem; Akkoc, Yunus; Bayraktar, Oznur; Gozuacik, Devrim
    y. Autophagy and apoptosis are two important molecular mechanisms that maintain cellular homeostasis under stress conditions. Autophagy represents an intracellular mechanism responsible for turnover of organelles and long-lived proteins through a lysosome-dependent degradation pathway. Cell death signals or sustained stress might trigger programmed cell death pathways, and among them, apoptosis is the most extensively studied one. Recent studies indicate the presence of a complex interplay between autophagy and apoptosis. Physiological relevance of autophagyapoptosis crosstalk was mainly shown in vitro. However, in vivo consequences possibly exist both during health and disease. In this review, we will summarize the current knowledge about molecular mechanisms connecting autophagy and apoptosis, and about the significance of this crosstalk for human health.