Browsing by Subject "Diabetic neuropathy"

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    Effects of experimental diabetes in the noradrenergic and cholinergic nerves of the rat small intestine
    (Murcia: F. Hernández, 1990) Cuervas-Mons, M.; Morte, L.; Junquera, C.; Ramón y Cajal, S.
    An histochemical research on cholinergic and noradrenergic fibres of the adventitia layer and of the myenteric plexus of the terminal ileum from rats with streptozotocin-induced diabetes, after 20 weeks of evolution of the illness, was carried out to study changes in the innervation of the gut. The cholinergic nerves, revealed through their acetylcholinesterase activity, did not present alterations, but an evident reduction in number of the noradrenergic nerves and swollen intensely fluorescent varicosities, were observed, both in the perivascular and myenteric plexus of terminal ileum from diabetic animals.
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    Submucosal plexus of terminal ileum: a study of the cholinergic and noradrenergic nerves in rats with streptozotocin-induced diabetes
    (Murcia : F. Hernández, 1992) Morte, L.; Cuervas-Mons, M.; Junquera, C.; Ramón y Cajal, S.
    -In order to study the type and degree of the alterations in the innervation of the intestine in experimental diabetes, a histochemical study on the cholinergic and noradrenergic nerves of the submucosal plexus of terminal ileum from rats with streptozotocin-induced diabetes was performed. The results obtained suggest that the diabetic animals keep the cholinergic activity undamaged 20 weeks after the induction of the illness, while the number of the catecholaminergic nerves appears to be markedly reduced.
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    Treadmill training increases the size of A cells from the L5 dorsal root ganglia in diabetic rats
    (Murcia : F. Hernández, 2010) do Nascimento, Patricia S.; Malysz, Tais; Ilha, Jocemar; Araujo, Rafaela T.; Hermel, Erica E.S.; Kalil-Gaspar, Pedro I.; Faccioni-Heuser, María C.; Schaan, Beatriz D.; Achaval, Matilde
    The aim of this study was to evaluate the effects of physical training on the L5 dorsal root ganglion (DRG) cells in streptozotocin diabetic rats. Male adult rats were divided into 3 groups: (control, diabetic and trained diabetic). Treadmill training was performed for 10 weeks (5 days/week, twice a day). Blood glucose concentrations and body weight were evaluated 48h after diabetes induction and every 30 days thereafter. Then, animals were killed and the right L5 DRG removed. Histological and morphometric analysis consisted of evaluating nuclear and cellular volumes and areas in A and B cells at light and ultrastructural levels. Blood glucose concentrations were higher in both diabetic groups vs controls at all periods. Body weights were lower in all diabetics vs controls at all periods after diabetes induction, with a significant time vs group interaction. In A cells, the cellular and nuclear volumes were lower than control animals only in the diabetic group; control and trained diabetic animals did not differ; in B cells the cellular and nuclear volumes were lower in diabetic and trained diabetic rats. The cellular areas of A cells were smaller in diabetic rats than in control and trained diabetic rats, while the cellular areas of B cells were smaller in the diabetic and trained groups. In conclusion, treadmill training was able to increase the size of A cells from the DRG in diabetic rats and improved the morphological features of these cells