Browsing by Subject "Crosstalk"

Now showing 1 - 2 of 2
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    Crosstalk between synovial macrophages and fibroblasts in rheumatoid arthritis
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2023) Saeki, Noritaka; Ima, Yuuki
    Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of joints. Abnormally activated cells such as synovial macrophages and synovial fibroblasts induce RA pathogenesis and ultimately joint destruction. Since macrophages can change their own characteristics depending on the microenvironmental condition, it has been suggested that activation and remission of RA are regulated by crosstalk between synovial macrophages and other cells. Moreover, recent findings of heterogeneity of synovial macrophages and fibroblasts support the idea that complex interactions regulate RA from its onset to remission. Importantly, an understanding of the intercellular crosstalk in RA is far from complete. Here, we summarize the molecular mechanisms underlying the pathological development of RA with particular reference to the crosstalk between synovial macrophages and fibroblasts.
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    Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Oral, Ozlem; Akkoc, Yunus; Bayraktar, Oznur; Gozuacik, Devrim
    y. Autophagy and apoptosis are two important molecular mechanisms that maintain cellular homeostasis under stress conditions. Autophagy represents an intracellular mechanism responsible for turnover of organelles and long-lived proteins through a lysosome-dependent degradation pathway. Cell death signals or sustained stress might trigger programmed cell death pathways, and among them, apoptosis is the most extensively studied one. Recent studies indicate the presence of a complex interplay between autophagy and apoptosis. Physiological relevance of autophagyapoptosis crosstalk was mainly shown in vitro. However, in vivo consequences possibly exist both during health and disease. In this review, we will summarize the current knowledge about molecular mechanisms connecting autophagy and apoptosis, and about the significance of this crosstalk for human health.