Browsing by Subject "Colorectal surgery"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Restricted
    Dietary modulation of gut microbiota in patients with colorectal cancer undergoing surgery: a review
    (Elsevier, 2022-07-05) Martínez-Montoro, José Ignacio; Martínez-Sánchez, María Antonia; Balaguer-Román, Andrés; Gil-Martínez, José; Mesa-López, María José; Egea Valenzuela, Juan; Ruiz Alcaraz, Antonio José; Queipo-Ortuño, María Isabel; Ferrer Gómez, Mercedes; Fernández García, José Carlos; Ramos-Molina, Bruno; Bioquímica y Biología Molecular B e Inmunología; Facultad de Biología
    Colorectal cancer (CRC) is the third most frequent malignancy and the second cause of cancer death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including physical inactivity, unhealthy dietary habits, obesity, and the gut microbiota. Emerging data suggest that the microbiome may play a key role in CRC prognosis and derived complications in patients undergoing colorectal surgery. On the other hand, dietary intervention has been demonstrated to be able to induce significant changes in the gut microbiota and related metabolites in different conditions; therefore, the manipulation of gut microbiota through dietary intervention may constitute a useful approach to improve perioperative dysbiosis and post-surgical outcomes in patients with CRC. In this article, we review the role of the gut microbiota in CRC surgery complications and the potential therapeutic modulation of gut microbiome through nutritional intervention in patients with CRC undergoing surgery.
  • Thumbnail Image
    Publication
    Open Access
    Gut microbiome modification through dietary intervention in patients with colorectal cancer: protocol for a prospective, interventional, controlled, randomized clinical trial in patients with scheduled surgical intervention for CRC
    (MDPI, 2022-06-22) Martínez-Sánchez, María Antonia; Núñez-Sánchez, María Ángeles; Balaguer-Román, Andrés; Oliva-Bolarín, Alba; Pujante-Gilabert, Gabriel; Hernández-Agüera, Quiteria; Mesa-López, María José; Egea Valenzuela, Juan; Queipo-Ortuño, María Isabel; Ruiz Alcaraz, Antonio José; Ferrer Gómez, Mercedes; Gil-Martínez, José; Ramos-Molina, Bruno; Bioquímica y Biología Molecular B e Inmunología; Facultad de Biología
    Colorectal cancer (CRC) is the third most common cancer and the second cause of cancer death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including heritable and environmental factors, which are the latest to be closely associated with nutritional habits, physical activity, obesity, and the gut microbiota. The latter may also play a key role in CRC prognosis and derived complications in patients undergoing surgery. This is a single-center, open, controlled, randomized clinical trial, in patients with scheduled surgical intervention for CRC. The primary objective is to assess whether a pre-surgical nutritional intervention, based on a high-fiber diet rich in polyunsaturated fatty acids (PUFAs), can reduce disturbances of the gut microbiota composition and, consequently, the rate of post-surgical complications in patients with CRC. Patients will be randomized in a 1:1 ratio after receiving a diagnosis of CRC. In the control arm, patients will receive standard nutritional recommendations, while patients in the intervention arm will be advised to follow a high-fiber diet rich in PUFAs before surgery. Participants will be followed up for one year to evaluate the overall rate of postsurgical complications, recurrences of CRC, response to adjuvant therapy, and overall/disease-free survival.