Browsing by Subject "Clumping"

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    Myocardial Connexin-43 and N-Cadherin decrease during vanadium inhalation
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Fortoul, Teresa I.; Soto-Mota, Adrian; Rojas-Lemus, Marcela; Rodriguez-Lara, Vilaney; GonzalezVillalva, Adriana; Montaño, Luis F.; Paez, Araceli; Colin-Barenque, Laura; López-Valdez, Nelly; Cano Gutiérrez, Gumaro; Bizarro-Nevares, Patricia; Ustarroz-Cano, Martha
    Particulate matter air pollution has considerably increased during the last decades; vanadium is a transition element adhered to this particulate matter, and the combustion of fossil fuels is the main source in the atmosphere. It has been reported that air pollution and specifically vanadium exposure increases the probability of suffering arrhythmias; however the biological mechanism of such a relationship remains unknown. It has been established that a diminished presence of NCadherin alters the Connexin-43 arrangement, and the consequent altered presence of these proteins predisposes to ventricular heart rate problems. We analyzed myocardial histology and the expression of N-Cadherin and Connexin-43 by immunohistochemistry in mouse that inhaled vanadium. Our results showed a significant and progressive reduction in both N-Cadherin and Connexin-43, as well as the presence of meganucleus; myofibrils disruption, and clumping in the exposed groups were also observed. Our findings add more information about a possible explanation for the arrythmogenic effect observed in dwellers of cities with high particulate matter atmospheric pollution.