Browsing by Subject "Chiasm"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Open Access
    El cuerpo en la filosofía de Merleau-Ponty
    (Universidad de Murcia. Servicio de Publicaciones, 2016) Firenze, Antonino
    El propósito de esta contribución es exponer los elementos esenciales de la filosofía del cuerpo de Merleau-Ponty. En un primer momento describiré la función trascendental del cuerpo como cogito tácito planteada en Phénoménologie de la perception, para a continuación poner de relieve la profundización ontológica que, con respecto a ésta, se esboza en Le visible et l’invisible. En efecto, en este contexto tardío, la comprensión de la corporeidad (lo visible) depende constitutivamente de su vínculo con el pensamiento (lo invisible). Mostraré que este quiasmo de visible e invisible remite de modo original al principio de productividad inmanente a la carne del mundo en cuanto que dimensión ontológica fundamental
  • Thumbnail Image
    Publication
    Open Access
    Visual deficits and diagnostic and therapeutic strategies for neurofibromatosis type 1: bridging science and patient-centered care
    (MDPI, 2024-05-09) Miyagishima, Kiyoharu J.; Qiao, Fengyu; Stasheff, Steven F.; Nadal-Nicolás, Francisco Manuel; Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica; Facultad de Óptica y Optometría
    Neurofibromatosis type 1 (NF1) is an inherited autosomal dominant disorder primarily affecting children and adolescents characterized by multisystemic clinical manifestations. Mutations in neurofibromin, the protein encoded by the Nf1 tumor suppressor gene, result in dysregulation of the RAS/MAPK pathway leading to uncontrolled cell growth and migration. Neurofibromin is highly expressed in several cell lineages including melanocytes, glial cells, neurons, and Schwann cells. Individuals with NF1 possess a genetic predisposition to central nervous system neoplasms, particularly gliomas affecting the visual pathway, known as optic pathway gliomas (OPGs). While OPGs are typically asymptomatic and benign, they can induce visual impairment in some patients. This review provides insight into the spectrum and visual outcomes of NF1, current diagnostic techniques and therapeutic interventions, and explores the influence of NF1-OPGS on visual abnormalities. We focus on recent advancements in preclinical animal models to elucidate the underlying mechanisms of NF1 pathology and therapies targeting NF1-OPGs. Overall, our review highlights the involvement of retinal ganglion cell dysfunction and degeneration in NF1 disease, and the need for further research to transform scientific laboratory discoveries to improved patient outcomes.