DigitalUM :: Browsing by Subject "Cell stress response"

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Open Access
Editorial: Cell stress responses and metabolic reprogramming in skin diseases
(Frontiers, 2023-03-01) Bastonini, Emanuela; Kovacs, Daniela; Lotti, Fiorenza; Sánchez del Campo Ferrer, Luis; Bioquímica y Biología Molecular A
Despite being in the challenging age of personalized and precision medicine, specific responses to external stressors may ultimately converge on common cell reprogramming mechanisms belonging to heterogeneous pathologies that range from metabolic disorders to cancer. Cell metabolism plays a crucial role in all living organisms and it is closely intertwined with multiple biochemical pathways, which should not simply viewed as a means to an end, since metabolic intermediates themselves can have huge functional importance. It is now recognized that there are many more metabolites, acting as signaling regulators than genes in the human genome. Perturbations of cell metabolism play an important role in both health and disease and perhaps their causative role is still underestimated. Certainly, some of those pathophysiological dysfunctions can result in cutaneous disorders.