Browsing by Subject "Cell associated antigen"

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    Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen
    (BMJ Publishing Group, 2019-04-08) Wculek, Stefanie K.; Amores Iniesta, Joaquín; Conde Garrosa, Ruth; Kouili, Sofía C.; Melero, Ignacio; Sancho, David; Sanidad Animal
    The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its full potential, despite the revolution in cancer immunotherapy. DCs are fundamental for CD8+ T cell activation, which relies on cross-presentation of exogenous antigen on MHC-I and can be fostered by immunogenic cancer cell death. Translational and clinical research has focused on in vitro-generated monocyte-derived DCs, while the vaccination efficacy of natural conventional type 1 DCs (cDC1s), which are associated with improved anti-tumor immunity and specialize on antigen cross-presentation, remains unknown.