Browsing by Subject "Breast carcinomas"

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    An immunocytochemical method for assaying oestrogen receptors in breast cancers. A comparison with the steroid binding assay
    (Murcia : F. Hernández, 1988) Ottestad, Lars; Tveit, Kjell M.; Nesland, Jahn M.; Dybsjordl, Indrejit; Bormer, Ole; Hoie, Johan; Pihl, Alexander
    The presence of oestrogen receptors was studied in 105 human breast carcinomas using monoclonal antibodies (Abbott ER-ICA kit). The oestrogen receptors of neoplastic cells were semiquantitatively measured and correlations were made to receptor values determined by a dextran-coated charcoal (DCC) steroid binding assay and to histological grade. Immunoreactive cells were found in about 213 of the tumours. Usually only a fraction of the cells within each tumour were immunoreactive, and the staining intensity varied among different cells. In general, well differentiated tumours had a greater proportion of immunoreactive cells than poorly differentiated ones. In most cases (651 98) a good agreement was found between the ER-ICA method and the DCC assay. However, in 33 cases discrepancies were demonstrated.