Browsing by Subject "Bone healing"

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    A new use for self-etching resin adhesives: Cementing bone fragments
    (Elsevier, 2010-06-18) Ortiz Ruiz, Antonio José; Vicente Hernández, Ascensión; Camacho Alonso, Fabio; López Jornet, P.; Dermatología, Estomatología, Radiología y Medicina Física
    Objectives: To evaluate the bond capacities of four self-etching resin cements and the self-etching adhesives of the same manufacturer when used to cement bone fragments and compare them with a well-known N-butyl-2-cyanoacrylate bone adhesive. Methods: 125 cylindrical bone specimens from pig mandibular ramus bone were prepared using terphane burs and cemented to the corticals of 125 other specimens obtained from pig mandibular body bone using the following bond systems: Group A: Adper PLP/Relyx; group B: Optibond/Maxcem; group C: Hystoacryl; group D: AdheSE/Multilink; group E: G-Bond/G-Cem. Shear bond strength was measured 15 min after cement application using a universal testing machine. Results: Shear bond strength results: group A 2.54 ± 0.23 MPa; group B 4.83 ± 0.4 MPa; group C 2.90 ± 0.24 MPa; group D 2.10 ± 0.17 MPa; group E 4.22 ± 0.24 MPa. Values for shear bond strength were significantly greater for group B and E compared to groups A, C and D (p < 0.005, test Mann–Whitney). SEM images showed the presence of a hybrid layer similar to that formed by these bond systems when used on dentine. Conclusion: Within the limitations of an in vitro investigation, results show that self-etching resin cements together with self-etching adhesives may be used for cementing bone fragments.
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    Advances in translational orthopaedic research with species-specific multipotent mesenchymal stromal cells derived from the umbilical cord
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2021) Ramallo, Melina; Carreras Sánchez, Irene; López Fernández, Alba; Vélez, Roberto; Aguirre, Màrius; Feldman, Sara; Vives, Joaquim
    Compliance with current regulations for the development of innovative medicines require the testing of candidate therapies in relevant translational animal models prior to human use. This poses a great challenge when the drug is composed of cells, not only because of the living nature of the active ingredient but also due to its human origin, which can subsequently lead to a xenogeneic response in the animals. Although immunosuppression is a plausible solution, this is not suitable for large animals and may also influence the results of the study by altering mechanisms of action that are, in fact, poorly understood. For this reason, a number of procedures have been developed to isolate homologous species-specific cell types to address preclinical pharmacodynamics, pharmacokinetics and toxicology. In this work, we present and discuss advances in the methodologies for derivation of multipotent Mesenchymal Stromal Cells derived from the umbilical cord, in general, and Wharton’s jelly, in particular, from medium to large animals of interest in orthopaedics research, as well as current and potential applications in studies addressing proof of concept and preclinical regulatory aspects.
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    Measurement of ridge alterations following tooth removal: a radiographic study in humans
    (Wiley, 2010-01-11) Moya Villaescusa, María José; Sánchez Pérez, A.; Dermatología, Estomatología, Radiología y Medicina Física
    Objective: The aim of this study was a radiographic mesiodistal analysis of the shape of the bone crest 3 months after tooth removal. Material and methods: One hundred single tooth extractions were performed on 100 patients because of orthodontic or prosthetic causes. Bite blocks were used for two radiographs: one on the day of extraction and the other after healing of the socket, 3 months later. These X-rays were used to determine: (1) the most apical distance of alveolar ridge resorption, with baseline as the line between bone-to-teeth contact (the greatest distance in bone resorption height) and (2) the mesiodistal distance (MDD) and mesial and distal angles arising after bone tissue modeling. Results: Significant differences (P<0.05) emerged between the MDDs of multiple- [8 mm, 95% confidence interval (CI): 6.09, 9.90] and single-root teeth (5.60 mm, 95% CI: 4.80, 6.50). However, mesial or distal angles or the most apical distance of alveolar ridge resorption did not differ (mean distance in height=4.32 mm, 95% CI: 3.85, 4.78; mean angle=24°). Conclusions: In this study, the post-extraction mesiodistal bone distance between teeth adjacent to the edentulous ridge depends on the size of the edentulous space. Nevertheless, the distance does not affect the distance in bone loss height. The distance of bone resorption height reaches a balance at the midpoint, which we consider indicative of stable healing. This resorption process must be considered when placing dental implants in fresh extraction sockets, especially in aesthetic sites, because the implant surfaces could be exposed after 3 months.