Browsing by Subject "Benchmarks"

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    Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study
    (Lippincott, Williams & Wilkins, ) Breuer, Eva; Mueller, Matteo; Doyle, Majella B.; Yang, Liu; Darwish Murad, Sarwa; Ramirez, Pablo; Clavien, Pierre-Alain; Cirugía, Pediatría y Obstetricia y Ginecología
    Objective: To define benchmark values for liver transplantation (LT) in patients with perihilar cholangiocarcinoma (PHC) enabling unbiased comparisons. Background: Transplantation for PHC is used with reluctance in many centers and even contraindicated in several countries. Although benchmark values for LT are available, there is a lack of specific data on LT performed for PHC. Methods: PHC patients considered for LT after Mayo-like protocol were analyzed in 17 reference centers in 2 continents over the recent 5-year period (2014–2018). The minimum follow-up was 1 year. Benchmark patients were defined as operated at high-volume centers ( ≥ 50 overall LT/year) after neoadjuvant chemoradiotherapy, with a tumor diameter <3 cm, negative lymph nodes, and with the absence of relevant comorbidities. Benchmark cutoff values were derived from the 75th to 25th percentiles of the median values of all benchmark centers. Results: One hundred thirty-four consecutive patients underwent LT after completion of the neoadjuvant treatment. Of those, 89.6% qualified as benchmark cases. Benchmark cutoffs were 90-day mortality ≤ 5.2%; comprehensive complication index at 1 year of ≤ 33.7; grade ≥ 3 complication rates ≤ 66.7%. These values were better than benchmark values for other indications of LT. Five-year disease-free survival was largely superior compared with a matched group of nodal negative patients undergoing curative liver resection (n = 106) (62% vs 32%, P < 0.001). Conclusion: This multicenter benchmark study demonstrates that LT offers excellent outcomes with superior oncological results in early stage PHC patients, even in candidates for surgery. This provocative observation should lead to a change in available therapeutic algorithms for PHC.
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    Splash-4: Improving Scalability with Lock-Free Constructs
    (2021-04) Gómez-Hernández, Eduardo José; Shao, Ruixiang; Sakalis, Christos; Kaxiras, Stefanos; Ros, Alberto; Ingeniería y Tecnología de Computadores
    Over the past three decades, the parallel applications of the Splash-2 benchmark suite have been instrumental in advancing multiprocessor research. Recently, the Splash-3 benchmarks eliminated performance bugs, data races, and improper synchronization that plagued Splash-2 benchmarks after the definition of the C memory model. In this work, we revisit the Splash-3 benchmarks and adapt them for contemporary architectures with atomic operations and lock-free constructs. With our changes, we improve the scalability of most benchmarks for up to 32 and 64 cores, showing an improvement of up to 9x in actual machines, and up to 5x in simulation, over the unmodified Splash-3 benchmarks. To denote the substantive nature of the improvements in the Splash-3 benchmarks and to re-introduce them in contemporary research, we refer to the new collection as Splash-4.